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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 38: D-3-phosphoglycerate dehydrogenase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoglycerate dehydrogenase. [EC: 1.1.1.95]
3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.
  • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
  • The reaction occurs predominantly in the direction of reduction.
  • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
 176 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A0H3LD71 A0A0H3LD71 A0A0H3LD71
(166 more...)
2-oxoglutarate reductase. [EC: 1.1.1.399]
(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH.
  • The enzyme catalyzes a reversible reaction.
  • The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate.
  • The SerA enzyme from Escherichia coli can also accept (S)-2- hydroxyglutarate with a much higher Km, and also catalyzes the activity of EC 1.1.1.95.
 164 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A085C732 A0A0H3LD71 A0A0H3LD71 A0A0H3LD71
(154 more...)
Malate dehydrogenase. [EC: 1.1.1.37]
(S)-malate + NAD(+) = oxaloacetate + NADH.
  • Also oxidizes some other 2-hydroxydicarboxylic acids.
 24 A0A158SIP3 A0A158SIP3 A0A158SIP3 A0A158SIP3 A0A2K6D631 A0A2K6D631 A0A2K6D631 A0A2K6D631 A0A481BII5 A0A481BII5
(14 more...)
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    		 1 Q9X1C1
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