The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: Adenylyltransferase and sulfurtransferase MOCS3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI) P12282 (/IPI)
(11 more)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
18 Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q8EKF6 (/ISS) Q8ID54 (/ISS) Q8ID54 (/ISS)
(8 more)
Molybdopterin-synthase adenylyltransferase activity GO:0061605
Catalysis of the reaction: ATP
13 P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA)
(3 more)
Sulfotransferase activity GO:0008146
Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
10 P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA)
Transferase activity, transferring sulfur-containing groups GO:0016782
Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor).
10 P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS)
Thiosulfate sulfurtransferase activity GO:0004792
Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate.
8 P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA)
Nucleotidyltransferase activity GO:0016779
Catalysis of the transfer of a nucleotidyl group to a reactant.
8 P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA)
Nucleotidyltransferase activity GO:0016779
Catalysis of the transfer of a nucleotidyl group to a reactant.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
Sulfurtransferase activity GO:0016783
Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
8 P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA)
Sulfurtransferase activity GO:0016783
Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
URM1 activating enzyme activity GO:0042292
Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.
8 P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
8 P38820 (/IPI) P38820 (/IPI) P38820 (/IPI) P38820 (/IPI) P38820 (/IPI) P38820 (/IPI) P38820 (/IPI) P38820 (/IPI)
Protein adenylyltransferase activity GO:0070733
Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
6 Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
2 Q386S6 (/ISM) Q386S6 (/ISM)
Mo-molybdopterin cofactor sulfurase activity GO:0008265
Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.
1 Q9ZNW0 (/ISS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mo-molybdopterin cofactor biosynthetic process GO:0006777
The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
13 P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP) P12282 (/IMP)
(3 more)
Mo-molybdopterin cofactor biosynthetic process GO:0006777
The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
12 Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q888B9 (/ISS) Q8EKF6 (/ISS) Q9KLX3 (/ISS) Q9KLX3 (/ISS)
(2 more)
Cysteine biosynthetic process from serine GO:0006535
The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.
10 P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS)
Cysteine biosynthetic process GO:0019344
The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
10 P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA) P9WMN7 (/IDA)
Active evasion of host immune response GO:0042783
Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
10 P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP) P9WMN7 (/IMP)
Invasive growth in response to glucose limitation GO:0001403
A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
8 P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI)
Invasive growth in response to glucose limitation GO:0001403
A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
TRNA wobble uridine modification GO:0002098
The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
TRNA wobble position uridine thiolation GO:0002143
The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
Cell budding GO:0007114
A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell.
8 P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI) P38820 (/IGI)
Enzyme active site formation via cysteine modification to L-cysteine persulfide GO:0018192
The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
Protein urmylation GO:0032447
Covalent attachment of the ubiquitin-like protein URM1 to another protein.
8 P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA) P38820 (/IDA)
Protein urmylation GO:0032447
Covalent attachment of the ubiquitin-like protein URM1 to another protein.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
TRNA thio-modification GO:0034227
The addition a sulfur atom to a nucleotide in a tRNA molecule.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
Regulation of pseudohyphal growth GO:2000220
Any process that modulates the frequency, rate or extent of pseudohyphal growth.
8 P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP) P38820 (/IMP)
Regulation of cell cycle process GO:0010564
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
6 Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA)
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
6 Q8ID54 (/EXP) Q8ID54 (/EXP) Q8ID54 (/EXP) Q8ID54 (/EXP) Q8ID54 (/EXP) Q8ID54 (/EXP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA) P12282 (/IDA)
(3 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
10 P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA) P9WMN7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS) P9WMN7 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P38820 (/HDA) P38820 (/HDA) P38820 (/HDA) P38820 (/HDA) P38820 (/HDA) P38820 (/HDA) P38820 (/HDA) P38820 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 Q8ID54 (/ISS) Q8ID54 (/ISS) Q8ID54 (/ISS) Q8ID54 (/ISS) Q8ID54 (/ISS) Q8ID54 (/ISS)
Apicoplast GO:0020011
The plastid organelle found in apicomplexans.
6 Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA) Q8ID54 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q386S6 (/IDA) Q386S6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q386S6 (/IDA) Q386S6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E9ADE6 (/ISO)