The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 323: Estradiol 17-beta-dehydrogenase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
|
5 | B3DK36 (/IDA) F1QUP2 (/IDA) P14061 (/IDA) P51657 (/IDA) Q7T2J0 (/IDA) |
|
Steroid dehydrogenase activity GO:0016229
Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.
|
3 | B3DK36 (/IDA) F1QUP2 (/IDA) Q7T2J0 (/IDA) |
|
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Testosterone dehydrogenase (NAD+) activity GO:0047035
Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
NADP+ binding GO:0070401
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
1 | P14061 (/TAS) |
|
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
|
1 | D3Z6W3 (/IDA) |
|
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
|
1 | Q9NYR8 (/TAS) |
|
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
|
1 | P14061 (/IDA) |
|
Testosterone dehydrogenase (NAD+) activity GO:0047035
Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.
|
1 | P51657 (/IDA) |
|
NADP-retinol dehydrogenase activity GO:0052650
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
|
1 | Q9N126 (/TAS) |
|
NADP+ binding GO:0070401
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
|
1 | P14061 (/IMP) |
|
Estradiol binding GO:1903924
Interacting selectively and non-covalently with estradiol.
|
1 | P14061 (/IDA) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
|
4 | B3DK36 (/IDA) F1QUP2 (/IDA) P51657 (/IDA) Q7T2J0 (/IDA) |
|
Androgen metabolic process GO:0008209
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
|
3 | B3DK36 (/IDA) F1QUP2 (/IDA) Q7T2J0 (/IDA) |
|
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
|
2 | P14061 (/TAS) Q9NYR8 (/TAS) |
|
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Testosterone biosynthetic process GO:0061370
The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Estrogen biosynthetic process GO:0006703
The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
|
1 | P14061 (/TAS) |
|
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
1 | D3Z6W3 (/IMP) |
|
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
1 | Q9NYR8 (/TAS) |
|
Estrogen metabolic process GO:0008210
The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
|
1 | P14061 (/TAS) |
|
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
|
1 | D3Z6W3 (/IDA) |
|
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
|
1 | P51657 (/IEP) |
|
Testosterone biosynthetic process GO:0061370
The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.
|
1 | P51657 (/IDA) |
|
Cellular response to metal ion GO:0071248
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
|
1 | P51657 (/IEP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | A0A0A0MQS7 (/IDA) P14061 (/IDA) P51657 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P51656 (/ISO) P51656 (/ISO) |
|
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
|
1 | Q9N126 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P51657 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P14061 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P14061 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9NYR8 (/TAS) |