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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 315: (+)-neomenthol dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Salutaridine reductase (NADPH). [EC: 1.1.1.248]
Salutaridinol + NADP(+) = salutaridine + NADPH.
  • Catalyzes the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant.
 2 A4UHT7 Q071N0
(-)-isopiperitenone reductase. [EC: 1.3.1.82]
(+)-cis-isopulegone + NADP(+) = (-)-isopiperitenone + NADPH.
  • The reaction occurs in the opposite direction to that shown above.
  • Participates in the menthol-biosynthesis pathway of Mentha plants.
  • (+)-pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates.
  • Has a preference for NADPH as the reductant, with NADH being a poor substitute.
  • Highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product.
 1 Q6WAU1