View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 299: Bifunctional pinoresinol-lariciresinol reductase 1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(+)-pinoresinol reductase. [EC: 1.23.1.1]
(+)-lariciresinol + NADP(+) = (+)-pinoresinol + NADPH.
  • The reaction is catalyzed in vivo in the opposite direction to that shown.
  • A multifunctional enzyme that further reduces the product to the lignan (-)-secoisolariciresinol (EC 1.23.1.2).
  • Isolated from the plants Forsythia intermedia, Thuja plicata (western red cedar), Linum perenne (perennial flax) and Linum corymbulosum.
  • The 4-pro-R hydrogen of NADH is transferred to the 7-pro-R position of lariciresinol.
 12 A0A178WJY2 A0A178WJY2 A3R052 B5KRH5 E6Y2X0 P93143 Q4R0I0 Q9FVQ6 Q9FVQ6 Q9LD12
(2 more...)
(-)-pinoresinol reductase. [EC: 1.23.1.3]
(-)-lariciresinol + NADP(+) = (-)-pinoresinol + NADPH.
  • The reaction is catalyzed in vivo in the opposite direction to that shown.
  • A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol (EC 1.23.1.4).
  • Isolated from the plants Thuja plicata (western red cedar), Linum perenne (perennial flax) and Arabidopsis thaliana (thale cress).
 8 A0A178WJY2 A0A178WJY2 Q4R0H9 Q9FVQ6 Q9FVQ6 Q9LD13 Q9LD14 Q9SVP6
(+)-lariciresinol reductase. [EC: 1.23.1.2]
(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + NADPH.
  • The reaction is catalyzed in vivo in the opposite direction to that shown.
  • A multifunctional enzyme that also reduces (+)-pinoresinol (EC 1.23.1.1).
  • Isolated from the plants Forsythia intermedia, Thuja plicata (western red cedar), Linum perenne (perennial flax) and Linum corymbulosum.
 6 B5KRH5 E6Y2X0 P93143 Q4R0I0 Q9LD12 Q9LD13
(-)-lariciresinol reductase. [EC: 1.23.1.4]
(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + NADPH.
  • The reaction is catalyzed in vivo in the opposite direction to that shown.
  • A multifunctional enzyme that also reduces (-)-pinoresinol (EC 1.23.1.3).
  • Isolated from the plants Thuja plicata (western red cedar) and Linum corymbulosum.
 3 A3R052 Q4R0H9 Q9LD14