The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 288: 2,4-dienoyl-CoA reductase, mitochondrial
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670
Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.
|
4 | Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
|
4 | Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670
Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.
|
3 | Q64591 (/ISS) Q9CQ62 (/ISS) Q9CQ62 (/ISS) |
|
2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670
Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |
|
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |
|
2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670
Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.
|
1 | Q64591 (/TAS) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
6 | G3V734 (/ISS) Q16698 (/ISS) Q16698 (/ISS) Q16698 (/ISS) Q16698 (/ISS) Q64591 (/ISS) |
|
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
4 | Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
4 | Q16698 (/TAS) Q16698 (/TAS) Q16698 (/TAS) Q16698 (/TAS) |
|
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
4 | Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
3 | Q64591 (/ISS) Q9CQ62 (/ISS) Q9CQ62 (/ISS) |
|
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |
|
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |
|
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
|
2 | Q9CQ62 (/IMP) Q9CQ62 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q93761 (/IMP) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | Q93761 (/IMP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
8 | A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
8 | A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) A0A024R9D7 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) Q16698 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q16698 (/HDA) Q16698 (/HDA) Q16698 (/HDA) Q16698 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
4 | Q16698 (/NAS) Q16698 (/NAS) Q16698 (/NAS) Q16698 (/NAS) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
4 | Q16698 (/TAS) Q16698 (/TAS) Q16698 (/TAS) Q16698 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q9CQ62 (/HDA) Q9CQ62 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9CQ62 (/ISO) Q9CQ62 (/ISO) |