The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 274: SUMO-activating enzyme subunit 1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
12 |
A2VE14 (/ISS)
A2VE14 (/ISS)
Q28DS0 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q6AXQ0 (/ISS)
(2 more) |
|
Ubiquitin activating enzyme activity GO:0004839
Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
|
6 | Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
6 | Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) |
|
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
6 | Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) |
|
ATP-dependent protein binding GO:0043008
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.
|
6 | Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) |
|
Small protein activating enzyme binding GO:0044388
Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
|
6 | Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
6 | Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
6 | Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) Q9UBE0 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
6 | Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q9R1T2 (/ISO) |
|
ATP-dependent protein binding GO:0043008
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.
|
1 | Q9R1T2 (/ISO) |
|
Small protein activating enzyme binding GO:0044388
Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
|
1 | Q9R1T2 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q9R1T2 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
14 |
A2VE14 (/ISS)
A2VE14 (/ISS)
Q28DS0 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q6AXQ0 (/ISS)
(4 more) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
7 | Q6IQS6 (/IMP) Q9UBE0 (/IMP) Q9UBE0 (/IMP) Q9UBE0 (/IMP) Q9UBE0 (/IMP) Q9UBE0 (/IMP) Q9UBE0 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
6 | Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
6 | Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
6 | Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) |
|
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
|
6 | Q9UBE0 (/HMP) Q9UBE0 (/HMP) Q9UBE0 (/HMP) Q9UBE0 (/HMP) Q9UBE0 (/HMP) Q9UBE0 (/HMP) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
1 | Q9R1T2 (/ISO) |
|
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
|
1 | Q6IQS6 (/IMP) |
|
Hematopoietic stem cell homeostasis GO:0061484
Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.
|
1 | Q6IQS6 (/IMP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
14 |
A2VE14 (/ISS)
A2VE14 (/ISS)
Q28DS0 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q5NVN7 (/ISS)
Q6AXQ0 (/ISS)
(4 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q9UBE0 (/HDA) Q9UBE0 (/HDA) Q9UBE0 (/HDA) Q9UBE0 (/HDA) Q9UBE0 (/HDA) Q9UBE0 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q9UBE0 (/NAS) Q9UBE0 (/NAS) Q9UBE0 (/NAS) Q9UBE0 (/NAS) Q9UBE0 (/NAS) Q9UBE0 (/NAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) Q9UBE0 (/TAS) |
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
6 | Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) Q9UBE0 (/IDA) |
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
1 | Q9R1T2 (/ISO) |
