The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 221: Enoyl-[acyl-carrier-protein] reductase [NADH]

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-[acyl-carrier-protein] reductase (NADH). [EC: 1.3.1.9]
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
  • The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety.
  • The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18.
  • The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.
424 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06
(414 more...)
Trans-2-enoyl-CoA reductase (NAD(+)). [EC: 1.3.1.44]
Acyl-CoA + NAD(+) = trans-didehydroacyl-CoA + NADH.
  • The enzyme from Euglena gracilis acts on crotonoyl-CoA and, more slowly, on trans-hex-2-enoyl-CoA and trans-oct-2-enoyl-CoA.
199 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06 A0A069QB06
(189 more...)
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