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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 215: 3-hydroxyacyl-CoA dehydrogenase type-2

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3(or 17)-beta-hydroxysteroid dehydrogenase. [EC: 1.1.1.51]
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
  • Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
 20 A0A0S2Z410 A0A0S2Z410 A0A0S2Z410 A0A0S2Z410 A0A2R9ANQ0 A0A2R9ANQ0 A0A2R9ANQ0 A0A2R9ANQ0 H2QYN3 H2QYN3
(10 more...)
3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.35]
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
  • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
  • Some enzymes act, more slowly, with NADP(+).
  • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
 20 A0A0S2Z410 A0A0S2Z410 A0A0S2Z410 A0A0S2Z410 A0A2R9ANQ0 A0A2R9ANQ0 A0A2R9ANQ0 A0A2R9ANQ0 H2QYN3 H2QYN3
(10 more...)
3-hydroxy-2-methylbutyryl-CoA dehydrogenase. [EC: 1.1.1.178]
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.
  • Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
 20 A0A0S2Z410 A0A0S2Z410 A0A0S2Z410 A0A0S2Z410 A0A2R9ANQ0 A0A2R9ANQ0 A0A2R9ANQ0 A0A2R9ANQ0 H2QYN3 H2QYN3
(10 more...)
Ipsdienol dehydrogenase. [EC: 1.1.1.386]
(4R)-ipsdienol + NAD(P)(+) = ipsdienone + NAD(P)H.
  • The enzyme is involved in pheromone production by the pine engraver beetle, Ips pini.
 1 G5DGA8