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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 191: Methylglyoxal reductase (NADPH-dependent)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylglyoxal reductase (NADPH). [EC: 1.1.1.283]
(S)-lactaldehyde + NADP(+) = 2-oxopropanal + NADPH.
  • The enzyme from the yeast Saccharomyces cerevisiae catalyzes the reduction of a keto group in a number of compounds, forming enantiopure products.
  • Among the substrates are methylglyoxal (which is reduced to (S)- lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1- phenylpropan-1-one.
  • The enzyme differs from EC 1.1.1.78 which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
 7 A0A0U1CQX8 A0A0U1CQX8 A0A454J730 A0A454J730 P83775 P83775 Q12068
3-methylbutanal reductase. [EC: 1.1.1.265]
3-methylbutanol + NAD(P)(+) = 3-methylbutanal + NAD(P)H.
  • The enzyme purified from Saccharomyces cerevisiae catalyzes the reduction of a number of straight-chain and branched aldehydes, as well as some aromatic aldehydes.
 1 Q12068
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