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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 182: NAD-dependent malic enzyme

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malolactic enzyme. [EC: 4.1.1.101]
(S)-malate = (S)-lactate + CO(2).
  • The enzyme is involved in the malolactic fermentation of wine, which results in a natural decrease in acidity and favorable changes in wine flavors.
  • It has been purified from several lactic acid bacteria, including Leuconostoc mesenteroides, Lactobacillus plantarum, and Oenococcus oeni.
 20 A0A095AMW7 A0A2X0PGG9 A0A2X0PGG9 A0A2X0PGG9 A0A3B0GUB9 A0A3B0GUB9 A0A3B0GUB9 A0A3S7H336 A0A3S7H336 A0A3S7H336
(10 more...)
Malate dehydrogenase (oxaloacetate-decarboxylating). [EC: 1.1.1.38]
(1) (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. (2) Oxaloacetate = pyruvate + CO(2).
  • Unlike EC 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. EC 1.1.1.40.
 1 P40375
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). [EC: 1.1.1.40]
(1) (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. (2) Oxaloacetate = pyruvate + CO(2).
  • The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.
 1 Q6TU48