The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Malate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
121 Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS)
(111 more)
L-lactate dehydrogenase activity GO:0004459
Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
116 Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q81K80 (/ISS) Q81K80 (/ISS) Q81K80 (/ISS) Q81K80 (/ISS) Q81K80 (/ISS)
(106 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P49814 (/IPI) P49814 (/IPI) P49814 (/IPI) P49814 (/IPI) P49814 (/IPI)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
4 Q2GK85 (/ISS) Q2GK85 (/ISS) Q2GK85 (/ISS) Q5LXE1 (/ISS)
L-lactate dehydrogenase activity GO:0004459
Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
2 P00344 (/IDA) P00344 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
2 P00344 (/IDA) P00344 (/IDA)
L-lactate dehydrogenase activity GO:0004459
Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
1 Q9P7P7 (/ISM)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 Q74D53 (/ISS)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
126 Q2GK85 (/ISS) Q2GK85 (/ISS) Q2GK85 (/ISS) Q5LXE1 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS) Q6HSF4 (/ISS)
(116 more)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
52 Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS) Q81RW4 (/ISS)
(42 more)
L(+)-lactate biosynthetic process from pyruvate GO:0019246
The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.
5 Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q71ZD6 (/ISS) Q71ZD6 (/ISS)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 Q95028 (/IMP) Q95028 (/IMP)
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
2 Q95028 (/IMP) Q95028 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 O23569 (/IEP) O23569 (/IEP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 O23569 (/IEP) O23569 (/IEP)
Lactate metabolic process GO:0006089
The chemical reactions and pathways involving lactate, the anion of lactic acid.
1 Q9P7P7 (/IC)
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
1 Q9P7P7 (/NAS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O23569 (/IDA) O23569 (/IDA) O51114 (/IDA) O51114 (/IDA) O51114 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O23569 (/IDA) O23569 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9P7P7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P7P7 (/HDA)