The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 168: Fatty acid synthase subunit alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
|
2 | A0A1D8PK65 (/IMP) C8VRL0 (/IMP) |
|
3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315
Catalysis of the reaction: acyl-
|
2 | P19097 (/IMP) P19097 (/IMP) |
|
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0004316
Catalysis of the reaction: (3R)-3-hydroxyacyl-
|
2 | P19097 (/IDA) P19097 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P19097 (/IPI) P19097 (/IPI) |
|
Holo-[acyl-carrier-protein] synthase activity GO:0008897
Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
|
2 | P19097 (/IMP) P19097 (/IMP) |
|
GMP synthase activity GO:0003921
Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
|
1 | C8VRL0 (/RCA) |
|
Acetyl-CoA carboxylase activity GO:0003989
Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
|
1 | C8VRL0 (/RCA) |
|
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
|
1 | Q10289 (/IDA) |
|
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
|
1 | C8VRL0 (/ISA) |
|
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
|
1 | A0A1D8PK65 (/ISS) |
|
Fatty acid synthase activity GO:0004312
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
|
1 | C8VRL0 (/RCA) |
|
[acyl-carrier-protein] S-acetyltransferase activity GO:0004313
Catalysis of the reaction: acetyl-CoA +
|
1 | C8VRL0 (/RCA) |
|
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314
Catalysis of the reaction: malonyl-CoA +
|
1 | C8VRL0 (/RCA) |
|
3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315
Catalysis of the reaction: acyl-
|
1 | Q10289 (/ISO) |
|
3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315
Catalysis of the reaction: acyl-
|
1 | C8VRL0 (/RCA) |
|
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0004316
Catalysis of the reaction: (3R)-3-hydroxyacyl-
|
1 | Q10289 (/ISO) |
|
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0004316
Catalysis of the reaction: (3R)-3-hydroxyacyl-
|
1 | C8VRL0 (/RCA) |
|
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0004317
Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-
|
1 | C8VRL0 (/RCA) |
|
Enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0004318
Catalysis of the reaction: acyl-
|
1 | C8VRL0 (/RCA) |
|
Oleoyl-[acyl-carrier-protein] hydrolase activity GO:0004320
Catalysis of the reaction: oleoyl-
|
1 | C8VRL0 (/RCA) |
|
Fatty-acyl-CoA synthase activity GO:0004321
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
|
1 | C8VRL0 (/RCA) |
|
Holo-[acyl-carrier-protein] synthase activity GO:0008897
Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
|
1 | Q10289 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
3 | A0A1D8PK65 (/IMP) C8VRL0 (/IMP) G8BAW7 (/IMP) |
|
Long-chain fatty acid biosynthetic process GO:0042759
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.
|
3 | P19097 (/IMP) P19097 (/IMP) Q10289 (/IMP) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
2 | A0A1D8PK65 (/IMP) G8BAW7 (/IMP) |
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | Q10289 (/IDA) |
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | C8VRL0 (/ISA) |
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | A0A1D8PK65 (/ISS) |
|
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
1 | C8VRL0 (/RCA) |
|
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
|
1 | G8BAW7 (/IMP) |
|
Palmitic acid biosynthetic process GO:1900535
The chemical reactions and pathways resulting in the formation of palmitic acid.
|
1 | Q10289 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P19097 (/HDA) P19097 (/HDA) Q10289 (/HDA) |
|
Fatty acid synthase complex GO:0005835
A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.
|
3 | P19097 (/IDA) P19097 (/IDA) Q10289 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P19097 (/HDA) P19097 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P19097 (/IDA) P19097 (/IDA) |