View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 137: Hydroxysteroid (17-beta) dehydrogenase 3

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Very-long-chain 3-oxoacyl-CoA reductase. [EC: 1.1.1.330]
A very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH.
  • The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • The enzyme is active with substrates with chain length of C(16) to C(34), depending on the species.
  • Cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.
  • Formerly EC 1.1.1.n13 and EC 2.3.1.119.
 7 O70503 O70503 Q0VGQ1 Q0VGQ1 Q4R5G7 Q53GQ0 Q6P7R8
17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
  • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
 7 O70503 O70503 Q0VGQ1 Q0VGQ1 Q4R5G7 Q53GQ0 Q6P7R8
Testosterone 17-beta-dehydrogenase (NADP(+)). [EC: 1.1.1.64]
Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH.
  • Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
 6 O54939 P37058 P37058 P70385 Q6FH62 Q6FH62