The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 106: NEDD8-activating enzyme E1 catalytic subunit, puta...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 F1SFQ0 (/IPI) Q8C878 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI)
(2 more)
NEDD8 activating enzyme activity GO:0019781
Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.
12 Q8C878 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA)
(2 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
10 Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
10 Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
10 Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI) Q8TBC4 (/IPI)
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
1 Q99MI7 (/IPI)
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
1 Q8C878 (/ISO)
NEDD8 activating enzyme activity GO:0019781
Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.
1 Q99MI7 (/IMP)
NEDD8 activating enzyme activity GO:0019781
Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.
1 Q8C878 (/ISO)
NEDD8 activating enzyme activity GO:0019781
Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.
1 Q8C878 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8C878 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q99MI7 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q8C878 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
11 Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA)
(1 more)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
10 Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
10 Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
10 Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q8C878 (/IMP)
Endomitotic cell cycle GO:0007113
A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.
1 Q8C878 (/IMP)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
1 Q8C878 (/ISO)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
1 Q99MI7 (/TAS)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
1 Q9V6U8 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q99MI7 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8C878 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q8C878 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS) Q8TBC4 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
10 Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA) Q8TBC4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8C878 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9V6U8 (/IPI)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8C878 (/ISO)