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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 101: GDP-L-fucose synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GDP-L-fucose synthase. [EC: 1.1.1.271]
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
  • Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.
 268 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2 A0A069XSH2
(258 more...)
GDP-L-colitose synthase. [EC: 1.1.1.356]
GDP-beta-L-colitose + NAD(P)(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D- mannose + NAD(P)H.
  • The enzyme is involved in biosynthesis of L-colitose, a 3,6- dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyzes the reaction in the reverse direction.
  • The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar.
  • The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H.
 1 G4WJD3