The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 99: cryptochrome-1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
5 P97784 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P97784 (/IPI) Q16526 (/IPI) Q16526 (/IPI) Q16526 (/IPI) Q16526 (/IPI)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
5 P97784 (/IPI) Q16526 (/IPI) Q16526 (/IPI) Q16526 (/IPI) Q16526 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 Q16526 (/TAS) Q16526 (/TAS) Q16526 (/TAS) Q16526 (/TAS)
Blue light photoreceptor activity GO:0009882
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.
4 Q16526 (/NAS) Q16526 (/NAS) Q16526 (/NAS) Q16526 (/NAS)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
4 Q16526 (/IPI) Q16526 (/IPI) Q16526 (/IPI) Q16526 (/IPI)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P97784 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P97784 (/IPI)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P97784 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P97784 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 P97784 (/ISO)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 P97784 (/ISO)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
1 P97784 (/IPI)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
1 P97784 (/IDA)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
9 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q6ZZY0 (/ISS) Q70AD6 (/ISS) Q8QG61 (/ISS) Q8WP19 (/ISS)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
9 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q6ZZY0 (/ISS) Q70AD6 (/ISS) Q8QG61 (/ISS) Q8WP19 (/ISS)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
9 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q6ZZY0 (/ISS) Q70AD6 (/ISS) Q8QG61 (/ISS) Q8WP19 (/ISS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
DNA damage induced protein phosphorylation GO:0006975
The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q8QG61 (/ISS) Q8WP19 (/ISS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Response to glucagon GO:0033762
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of G protein-coupled receptor signaling pathway GO:0045744
Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Regulation of DNA damage checkpoint GO:2000001
Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
7 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 P97784 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA)
Blue light signaling pathway GO:0009785
The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.
4 Q16526 (/NAS) Q16526 (/NAS) Q16526 (/NAS) Q16526 (/NAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 Q32Q86 (/ISS) Q70AD6 (/ISS) Q8WP19 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P97784 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P97784 (/ISO)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 P97784 (/IMP)
DNA damage induced protein phosphorylation GO:0006975
The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage.
1 P97784 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P97784 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P97784 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P97784 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
1 P97784 (/IMP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 P97784 (/IMP)
Lipid storage GO:0019915
The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 P97784 (/IGI)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 P97784 (/IDA)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 P97784 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P97784 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 P97784 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 P97784 (/IMP)
Response to glucagon GO:0033762
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
1 P97784 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P97784 (/IGI)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P97784 (/IMP)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
1 P97784 (/IDA)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
1 P97784 (/IMP)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
1 P97784 (/IMP)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
1 P97784 (/IMP)
Negative regulation of G protein-coupled receptor signaling pathway GO:0045744
Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
1 P97784 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P97784 (/IGI)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P97784 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P97784 (/ISO)
Regulation of DNA damage checkpoint GO:2000001
Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.
1 P97784 (/IDA)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
1 P97784 (/IDA)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
1 P97784 (/IGI)
Negative regulation of glucocorticoid secretion GO:2000850
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion.
1 P97784 (/IGI)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 A0A091FX31 (/ISS) A0A098M0Y5 (/ISS) G1KQX0 (/ISS) J3RYW5 (/ISS) Q6ZZY0 (/ISS) T1DLQ9 (/ISS) U3KG30 (/ISS) W8DU92 (/ISS) X5D0Q5 (/ISS)
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
9 A0A091FX31 (/ISS) A0A098M0Y5 (/ISS) G1KQX0 (/ISS) J3RYW5 (/ISS) Q6ZZY0 (/ISS) T1DLQ9 (/ISS) U3KG30 (/ISS) W8DU92 (/ISS) X5D0Q5 (/ISS)
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
9 A0A091FX31 (/ISS) A0A098M0Y5 (/ISS) G1KQX0 (/ISS) J3RYW5 (/ISS) Q6ZZY0 (/ISS) T1DLQ9 (/ISS) U3KG30 (/ISS) W8DU92 (/ISS) X5D0Q5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q16526 (/ISS) Q32Q86 (/ISS) Q70AD6 (/ISS) Q8QG61 (/ISS) Q8WP19 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P97784 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA) Q16526 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 F1NYE9 (/IDA) Q8QG61 (/IDA)
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
2 F1NYE9 (/IDA) Q8QG61 (/IDA)
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
2 F1NYE9 (/IDA) Q8QG61 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P97784 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P97784 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P97784 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P97784 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P97784 (/TAS)
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