The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
von Willebrand factor, type A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Protein transport protein SEC23Protein transport protein SEC23SEC24 homolog B, COPII coat complex componentprotein transport protein Sec24D isoform X1Complement factor Bvon Willebrand factorVesicle coat componentTranscription factor TFIIH subunit Tfb4, putativeSC:2Integrin betaIntegrin, alpha 10General transcription factor IIH subunit 2Anthrax toxin receptor 1Collagen type VI alpha 3 chainAnthrax toxin receptorX-ray repair cross-complementing protein 6 isoform X160 kDa SS-A/Ro ribonucleoproteinvon Willebrand factorX-ray repair cross-complementing protein 5von Willebrand factorSporozoite surface protein 2Collagen, type XII, alpha 1Collagen type VI alpha 3 chaincollagen alpha-6(VI) chain26S proteasome non-ATPase regulatory subunit 4voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1Calcium voltage-gated channel auxiliary subunit alpha2delta 3Putative vitrinIntegrator complex subunit 6 likeinter-alpha-trypsin inhibitor heavy chain H2von Willebrand and RING finger domain proteinCollagen type VI alpha 3 chainMatrilin 1Collagen, type VI, alpha 3Collagen type VI alpha 3 chainVitrinCollagen, type VI, alpha 1collagen alpha-2(VI) chain isoform X1MidasinCochlinProtein ViaAHemicentin 1calcium-activated chloride channel regulator 1collagen alpha-3(VI) chain isoform X3Integrin betaCollagen type VI alpha 3 chainintegrator complex subunit 14 isoform X1VWFA and cache domain-containing protein 160 kDa SS-A/Ro ribonucleoprotein isoform X1Collagen alpha-1(XXI) chain isoform X1Copine 4Protein transport protein SEC23Collagen type VI alpha 6 chaingeneral transcription factor IIH subunit 3 isoform X1von Willebrand factor A domain-containing protein 1von Willebrand factor A domain containing 2von Willebrand factor A domain-related proteinvon Willebrand factor A domain containing 8Collagen, type VI, alpha 1Collagen type XXVIII alpha 1 chaincollagen alpha-2(VI) chain isoform X1von Willebrand factor A domain containing 2Protein transport protein SEC23von Willebrand factor A domain containing 2Calcium-activated chloride channel regulator 2Collagen, type VI, alpha 1Uncharacterized protein, isoform CRNA polymerase II transcription factor B subunit 4Complement C2von Willebrand factor, type AIntegrin alpha MATP-dependent DNA helicase 2 subunit KU70von Willebrand factor A domain containing 5Asushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1ATP-dependent DNA helicase II subunit 1collagen alpha-1(VII) chainATP-dependent DNA helicase II subunit 2Mediator complex subunit 25general transcription factor IIH subunit 3Uncharacterized protein, isoform BUPF0353 protein RN09_1826Mg-protoporphyrin IX chelataseX-ray repair-complementing defective repair in Chinese hamster cells 6Collagen type VI alpha 5 chainPoly [ADP-ribose] polymeraseCircumsporozoite-and TRAP-related proteinCircumsporozoite-and TRAP-related proteinTRAP-like proteinRNA polymerase II transcription factor B subunit 4Protein transport protein Sec24ASecretory 24AB, isoform AGeneral transcription factor IIH subunitMidasinTranscription initiation factor TFIIH subunitVoltage-dependent calcium channel subunit alpha-2/delta-3Dihydropyridine-sensitive l-type calcium channelIntegrin betaProtein transport protein Sec24-like CEFCopine-5Yku70pInter alpha-trypsin inhibitor, heavy chain-like proteinGeneral transcription factor IIH subunit, putativeATP-dependent DNA helicase 2 subunit KU80Sec23/sec24 transport family proteinUnplaced genomic scaffold supercont1.1, whole genome shotgun sequenceMesocentinNitric oxide reductase D proteinPutative ribonucleoprotein related-proteinSfb3pProtein transport protein SEC23Protein CBR-DIG-1Uncharacterized proteinTFIIH basal transcription factor subunitProtein CBR-CUT-6MidasinRetroelement pol polyprotein-likeVoltage-dependent calcium channel unc-36Protein CBR-TAG-180Collagen type VI alpha 6 chainMidasinComplement factor BMidasin, putativeMesocentinProtein transport protein SEC23ATP-dependent DNA helicase II subunit 2von Willebrand factor, type AVoltage-dependent calcium channel subunit alpha-2/delta-160 kDa SS-A/Ro ribonucleoprotein homolog26S proteasome regulatory subunit S5A (AFU_orthologue AFUA_2G15070)Probable E3 ubiquitin-protein ligase EDA40Inverted repeat-binding proteinUncharacterized protein60 kDa SS-A/Ro ribonucleoprotein homologProtein transport protein Sec24C, putativeEfk-1Alpha-protein kinase vwkAC-type LECtinIntegrator complex subunit 14general transcription factor IIH subunit 3 isoform X2Predicted proteinUncharacterized protein (Fragment)Matrilin-4Integrator complex subunit 6ATP-dependent DNA helicase II subunit 2RNA polymerase II transcription factor B subunit, putativeTelomerase-associated protein 1ATP-dependent DNA helicase II subunit 2Copine family proteinMidasinPredicted proteinProtein BONZAI 2Uncharacterized proteinTFIIH P44RfeFUncharacterized proteinCollagen, type VI, alpha 1General Transcription Factor homologUncharacterized proteinPredicted proteinCalcium voltage-gated channel auxiliary subunit alpha2delta 2Caenorhabditis KUMesocentinPredicted proteinIntegrin betaLOC553407 proteinPredicted proteinCollagen, type VI, alpha 3Collagen, type VI, alpha 1ATP-dependent DNA helicaseCollagen type VI alpha 3 chainCollagen, type VI, alpha 1Tellurium resistance proteinUncharacterized proteinCollagen, type VI, alpha 1Matrilin 1Complement factor BCopine-7Uncharacterized proteinUncharacterized proteinvon Willebrand factor type A domain proteinEpithelial chloride channel proteinUncharacterized proteinUncharacterized protein, isoform EPredicted proteinProteasome 26S subunit, non-ATPase 4Uncharacterized proteinUncharacterized proteinATP-dependent DNA helicase II subunit 2Uncharacterized proteinATP-dependent DNA helicase 2 subunit KU80Circularly permutated Ras protein 1Protein transport protein SEC23Integrin betaUbiquitin-conjugating enzyme family proteinCollagen, type VII, alpha 1Protein transport protein SEC23Uncharacterized proteinIntegrin betaIntegrin betaProtein transport protein SEC23ATP-dependent DNA helicase II subunit 2Predicted proteinATP-dependent DNA helicase II subunit 1KU80 proteinATP-dependent DNA helicase II subunit 2Integrin betaDNA binding proteinCku-70Voltage-dependent calcium channel subunit alpha-2/delta-1Ku70-like proteinATP-dependent DNA helicase II subunit 1von Willebrand factorPutative KU70 proteinATP-dependent DNA helicaseATP-dependent DNA helicase II subunit 1Collagen, type VI, alpha 4avon Willebrand factorUncharacterized proteinUncharacterized proteinABL030Wpvon Willebrand factorCollagen, type VI, alpha 4aMidasinUncharacterized proteinIntegrin betaIntegrin betaAGAP009043-PACollagen alpha-1(XIV) chain-likeUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinPutative 60 kd ribonucleoprotein ssa/ro60 kd ribonucleoprotein ssa/roUncharacterized proteinPredicted proteinDumPY: shorter than wild-typevon Willebrand factor type A domain containing protein, putativeIntegrator complex subunit 14TROVE domain proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinintegrator complex subunit 14VWA domain containing CoxE-like proteinUncharacterized proteinUncharacterized protein60-kDa SS-A/Ro ribonucleoprotein homologGeneral transcription and DNA repair factor IIH subunit TFB4Methanol oxidation proteinUncharacterized proteinUncharacterized proteinCutl-23Cutl-23ANTXR cell adhesion molecule 1dANTXR cell adhesion molecule 1dPredicted proteinVoltage-dependent calcium channel subunit alpha-2/delta-3voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1Voltage-dependent calcium channel subunit alpha-2/delta-4Uncharacterized proteinPredicted proteinPredicted proteinUncharacterized proteinCalcium voltage-gated channel auxiliary subunit alpha2delta 4Integrin betaPredicted proteinUncharacterized proteinCollagen, type XII, alpha 1bUncharacterized proteinUncharacterized proteinDNA binding proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinATP-dependent DNA helicase II subunit 2Protein transport protein SEC23Integrin betaUncharacterized proteinIntegrin betaUncharacterized proteinIntegrin betaUncharacterized proteinUncharacterized proteinProtein transport protein SEC23Integrin betaIntegrin betaKU70 proteinInverted repeat-binding proteinUncharacterized proteinX-ray repair cross-complementing protein 5-like ProteinUncharacterized proteinCollagen type VI alpha 3 chainPredicted proteinPredicted proteinPredicted proteinUbiquitin interaction motif family proteinPoly [ADP-ribose] polymeraseUbiquitin-conjugating enzyme family proteinSec24d proteinIntegrin betaUncharacterized proteinATP dependent DNA ligase 1Uncharacterized proteinSerine/threonine protein kinase PpkAIntegrin betaUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinMesocentinUncharacterized proteinUncharacterized proteinPhospholipase A(2)Integrin betaIntegrin betaPredicted proteinUncharacterized proteinUncharacterized proteinCollagen, type XIV, alpha 1aIntegrin betaUncharacterized proteinUncharacterized proteinProtein transport protein SEC2360 kDa SS-A/Ro ribonucleoprotein-like ProteinIntegrin betaTFIIH P34Uncharacterized proteinProtein transport protein SEC23Uncharacterized proteinChloride channel accessory 3, pseudogeneUncharacterized proteinSec24-related gene family, member C (S. cerevisiae)AGAP001871-PAUncharacterized proteinUncharacterized proteinFibronectin binding proteinUncharacterized proteinPredicted proteinUncharacterized proteinAnthrax toxin receptorIntegrin beta-like protein CUncharacterized proteinUncharacterized proteinUncharacterized proteinIntegrin betaProteasome 26S subunit, non-ATPase 4Uncharacterized proteinProtein transport protein SEC23Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinVwa2 proteinUncharacterized proteinProtein transport protein SEC23TFIIH 34kDa subunitCollagen, type VI, alpha 3Bcl-2-associated transcription factor (BTF), putativeUncharacterized proteinUncharacterized proteinType IV pili system adhesin PilYGeneral transcription and DNA repair factor IIH subunit tfb4MxaL proteinUncharacterized proteinUncharacterized proteinPredicted protein60 kDa SS-A/Ro ribonucleoprotein homologUncharacterized proteinPredicted proteinUncharacterized proteinvoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent calcium channel subunit alpha-2/delta-4-like ProteinCalcium voltage-gated channel auxiliary subunit alpha2delta 3Uncharacterized proteinUncharacterized proteinCollagen alpha 3 chain type VI
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FunFam 65: Complement C2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC TermAnnotationsEvidence
Classical-complement-pathway C3/C5 convertase. [EC: 3.4.21.43]
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
  • A complex of complement fragments C4b, C2a and C2b.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.44.
8 P06681 P06681 P21180 Q5JP69 Q5JP69 Q863A0 Q8SQ74 Q8SQ75
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