The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
von Willebrand factor, type A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Integrin beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 71 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
25 A0A0G2JWK0 (/IPI) B3DIP9 (/IPI) L7RT22 (/IPI) L7RT22 (/IPI) O54890 (/IPI) O70309 (/IPI) P05106 (/IPI) P05107 (/IPI) P05556 (/IPI) P05556 (/IPI)
(15 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
9 A0A286Y9W0 (/IPI) B2RYB8 (/IPI) B3DHB6 (/IPI) F1QG85 (/IPI) P11584 (/IPI) P11584 (/IPI) P49134 (/IPI) Q3YAA0 (/IPI) Q3YAA1 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
7 A5Z1X6 (/ISS) B0FYY4 (/ISS) P09055 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
6 O54890 (/IPI) O70309 (/IPI) P05106 (/IPI) P09055 (/IPI) P49134 (/IPI) Q9Z0T9 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 B2RYB8 (/IPI) P05556 (/IPI) P05556 (/IPI) P49134 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
4 O54890 (/ISO) P09055 (/ISO) P11835 (/ISO) P26011 (/ISO)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
3 A0A286Y9W0 (/IGI) F1QG85 (/IGI) Q3YAA1 (/IGI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
3 P05556 (/IPI) P05556 (/IPI) P49134 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 P05556 (/IDA) P05556 (/IDA) P49134 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 A0A0G2JVU1 (/IPI) D3ZP06 (/IPI) P49134 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 O70309 (/ISO) P09055 (/ISO) Q0VBD0 (/ISO)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
3 P05106 (/TAS) P05556 (/TAS) P05556 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 P05107 (/NAS) P05556 (/NAS) P05556 (/NAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 P05107 (/TAS) P05556 (/TAS) P05556 (/TAS)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
3 P05106 (/IPI) P05556 (/IPI) P05556 (/IPI)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
2 P05556 (/IPI) P05556 (/IPI)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
2 O54890 (/ISO) P09055 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 O54890 (/ISO) P09055 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 O54890 (/ISO) P09055 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 O54890 (/IPI) P05106 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P05107 (/IPI) P49134 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P09055 (/ISO) P11835 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P09055 (/ISO) P11835 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
2 P05556 (/HDA) P05556 (/HDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P05556 (/IDA) P05556 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P09055 (/ISO) P11835 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 P05107 (/IMP) P26010 (/IMP)
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
2 P05556 (/IMP) P05556 (/IMP)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
2 F1N8N7 (/IPI) P07228 (/IPI)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 P11835 (/IMP)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 P05107 (/ISS)
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
1 P11835 (/IGI)
Complement component C3b binding GO:0001851
Interacting selectively and non-covalently with the C3b product of the complement cascade.
1 P05107 (/ISS)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
1 P49134 (/IDA)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
1 P05106 (/IMP)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P05106 (/IDA)
Protein disulfide isomerase activity GO:0003756
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
1 P05106 (/IDA)
Protein disulfide isomerase activity GO:0003756
Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
1 O54890 (/ISO)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 P09055 (/ISO)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 O54890 (/IPI)
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
1 P05106 (/TAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P49134 (/IMP)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 P49134 (/IDA)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 P09055 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 O54890 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P49134 (/IPI)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P09055 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P49134 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P09055 (/ISO)
ICAM-3 receptor activity GO:0030369
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
1 P05107 (/IMP)
ICAM-3 receptor activity GO:0030369
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
1 P11835 (/ISO)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 P05107 (/IPI)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 P11835 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P05106 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O54890 (/ISO)
Vascular endothelial growth factor receptor 2 binding GO:0043184
Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.
1 P05106 (/IPI)
Vascular endothelial growth factor receptor 2 binding GO:0043184
Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.
1 O54890 (/ISO)
Vascular endothelial growth factor receptor 2 binding GO:0043184
Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.
1 P05106 (/TAS)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 P49134 (/IDA)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 P49134 (/IMP)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 P09055 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P49134 (/IMP)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
1 P05106 (/IDA)
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
1 O54890 (/ISO)
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
1 P49134 (/IDA)
Alpha-actinin binding GO:0051393
Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
1 P09055 (/ISO)
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
1 P09055 (/ISO)
Extracellular matrix protein binding GO:1990430
Interacting selectively and non-covalently with a protein that is part of an extracellular matrix.
1 P26012 (/IDA)
Extracellular matrix protein binding GO:1990430
Interacting selectively and non-covalently with a protein that is part of an extracellular matrix.
1 Q0VBD0 (/ISO)

There are 369 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
18 A5Z1X6 (/ISS) B0FYY4 (/ISS) O54890 (/ISS) P05556 (/ISS) P05556 (/ISS) P07228 (/ISS) P09055 (/ISS) P18563 (/ISS) P49134 (/ISS) P53712 (/ISS)
(8 more)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
15 A5Z1X6 (/ISS) B0FYY4 (/ISS) P05107 (/ISS) P05556 (/ISS) P05556 (/ISS) P32592 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) P53714 (/ISS)
(5 more)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
15 A5Z1X6 (/ISS) B0FYY4 (/ISS) P05107 (/ISS) P05556 (/ISS) P05556 (/ISS) P32592 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) P53714 (/ISS)
(5 more)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
12 A8DSD5 (/IMP) O70309 (/IMP) P05107 (/IMP) P05556 (/IMP) P05556 (/IMP) P11584 (/IMP) P11584 (/IMP) P18084 (/IMP) P18084 (/IMP) P26010 (/IMP)
(2 more)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
9 P05106 (/TAS) P05107 (/TAS) P05556 (/TAS) P05556 (/TAS) P18084 (/TAS) P18084 (/TAS) P18564 (/TAS) P26010 (/TAS) P26012 (/TAS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
9 A5Z1X6 (/ISS) B0FYY4 (/ISS) P05556 (/ISS) P05556 (/ISS) P09055 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
8 A0A0G2JWK0 (/TAS) P05106 (/TAS) P05107 (/TAS) P18564 (/TAS) P26010 (/TAS) P26012 (/TAS) Q8R2H2 (/TAS) Q8R2H2 (/TAS)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
8 P05106 (/IMP) P05107 (/IMP) P05556 (/IMP) P05556 (/IMP) P09055 (/IMP) P18084 (/IMP) P18084 (/IMP) P26010 (/IMP)
Regulation of collagen catabolic process GO:0010710
Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
8 A5Z1X6 (/ISS) B0FYY4 (/ISS) P09055 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS)
Regulation of transforming growth factor beta activation GO:1901388
Any process that modulates the frequency, rate or extent of transforming growth factor beta activation.
8 P18563 (/ISS) P26012 (/ISS) P26013 (/ISS) Q1RPR6 (/ISS) Q6AYF4 (/ISS) Q863C4 (/ISS) Q8SQB8 (/ISS) Q9Z0T9 (/ISS)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
8 A5Z1X6 (/ISS) B0FYY4 (/ISS) P09055 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
7 P05106 (/IDA) P05556 (/IDA) P05556 (/IDA) P11584 (/IDA) P11584 (/IDA) P18564 (/IDA) Q9Z0T9 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
7 A0A0G2JWK0 (/IMP) B2RYB8 (/IMP) P05556 (/IMP) P05556 (/IMP) P26012 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996
Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.
6 P05107 (/ISS) P32592 (/ISS) P53714 (/ISS) Q2VJ42 (/ISS) Q5VI41 (/ISS) Q6ECI6 (/ISS)
Cell-substrate junction assembly GO:0007044
The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
5 O54890 (/ISO) O70309 (/ISO) P09055 (/ISO) P11835 (/ISO) P26011 (/ISO)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
5 P05106 (/IMP) P05556 (/IMP) P05556 (/IMP) P11584 (/IMP) P11584 (/IMP)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
5 P05106 (/IMP) P05107 (/IMP) P05556 (/IMP) P05556 (/IMP) P26010 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
5 B3DHB6 (/IMP) P09055 (/IMP) P11584 (/IMP) P11584 (/IMP) Q3YAA0 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 O70309 (/ISO) P09055 (/ISO) P11835 (/ISO) P26011 (/ISO)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
4 A0A0G2JWK0 (/IMP) P49134 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
4 A0A0G2JWK0 (/IMP) O54890 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
4 A0A0G2JWK0 (/IEP) P49134 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
4 P05556 (/TAS) P05556 (/TAS) P11584 (/TAS) P11584 (/TAS)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
4 O54890 (/ISO) P09055 (/ISO) P11835 (/ISO) P26011 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
4 O54890 (/ISO) P09055 (/ISO) P11835 (/ISO) Q0VBD0 (/ISO)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
4 P05107 (/TAS) P05556 (/TAS) P05556 (/TAS) P26010 (/TAS)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
4 P05106 (/TAS) P05107 (/TAS) P05556 (/TAS) P05556 (/TAS)
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
4 A0A0G2JWK0 (/IMP) P05106 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
4 A0A0G2JWK0 (/IEP) P49134 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
3 P05107 (/IDA) P05556 (/IDA) P05556 (/IDA)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
3 P05107 (/IDA) P05556 (/IDA) P05556 (/IDA)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O70309 (/IMP) P18084 (/IMP) P18084 (/IMP)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
3 A0A0G2JWK0 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
3 A0A0G2JWK0 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P05107 (/TAS) P05556 (/TAS) P05556 (/TAS)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
3 P05106 (/ISS) Q8R2H2 (/ISS) Q8R2H2 (/ISS)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
3 O54890 (/ISO) P09055 (/ISO) Q9Z0T9 (/ISO)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
3 P05106 (/IDA) P11584 (/IDA) P11584 (/IDA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 A0A0G2JWK0 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Endodermal cell differentiation GO:0035987
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
3 P05107 (/IEP) P18084 (/IEP) P18084 (/IEP)
Response to platelet-derived growth factor GO:0036119
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
3 A0A0G2JWK0 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
3 O70309 (/IMP) P18084 (/IMP) P18084 (/IMP)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Mesodermal cell differentiation GO:0048333
The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
3 P05106 (/IEP) P05556 (/IEP) P05556 (/IEP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
3 P05556 (/IMP) P05556 (/IMP) P26010 (/IMP)
Regulation of release of sequestered calcium ion into cytosol GO:0051279
Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
3 A0A0G2JWK0 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Regulation of serotonin uptake GO:0051611
Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell.
3 P05106 (/ISS) Q8R2H2 (/ISS) Q8R2H2 (/ISS)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of glomerular mesangial cell proliferation GO:0072126
Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway GO:1900731
Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway.
3 A0A0G2JWK0 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
3 A0A286Y9W0 (/IGI) F1QG85 (/IGI) Q3YAA1 (/IGI)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
3 A0A286Y9W0 (/IMP) F1QG85 (/IMP) Q3YAA1 (/IMP)
Cellular response to insulin-like growth factor stimulus GO:1990314
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
3 A0A0G2JWK0 (/IEP) Q8R2H2 (/IEP) Q8R2H2 (/IEP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 A0A2R8RTX7 (/IGI) F1QN46 (/IGI)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
2 A0A2R8RTX7 (/IGI) F1QN46 (/IGI)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
2 A0A2R8RTX7 (/IMP) F1QN46 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
2 P26013 (/ISS) Q0VBD0 (/ISS)
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
2 A0A2R8RTX7 (/IGI) F1QN46 (/IGI)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
2 A0A2R8RTX7 (/IGI) F1QN46 (/IGI)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
2 A0A2R8RTX7 (/IMP) F1QN46 (/IMP)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
2 P18084 (/TAS) P18084 (/TAS)
Pericardium morphogenesis GO:0003344
The process in which the anatomical structure of the pericardium is generated and organized.
2 P11584 (/IMP) P11584 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 P05556 (/ISS) P05556 (/ISS)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
2 P11584 (/IGI) P11584 (/IGI)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
2 P18084 (/TAS) P18084 (/TAS)
Cellular defense response GO:0006968
A defense response that is mediated by cells.
2 P05556 (/TAS) P05556 (/TAS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
2 P11584 (/IMP) P11584 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 P09055 (/ISO) P11835 (/ISO)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 P05556 (/TAS) P05556 (/TAS)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
2 P11584 (/TAS) P11584 (/TAS)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
2 P09055 (/ISO) P11835 (/ISO)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
2 O54890 (/IGI) P09055 (/IGI)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
2 P11584 (/TAS) P11584 (/TAS)
Calcium-independent cell-matrix adhesion GO:0007161
The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.
2 P05556 (/IGI) P05556 (/IGI)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P05106 (/TAS) P05107 (/TAS)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
2 P11584 (/IMP) P11584 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
2 B3DHB6 (/IGI) Q3YAA0 (/IGI)
Germ-band extension GO:0007377
Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further.
2 P11584 (/IMP) P11584 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 P11584 (/IMP) P11584 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 P11584 (/TAS) P11584 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 P11584 (/IMP) P11584 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2 P11584 (/IMP) P11584 (/IMP)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
2 P11584 (/IMP) P11584 (/IMP)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
2 P11584 (/IMP) P11584 (/IMP)
Apposition of dorsal and ventral imaginal disc-derived wing surfaces GO:0007475
The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.
2 P11584 (/NAS) P11584 (/NAS)
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
2 P11584 (/TAS) P11584 (/TAS)
Larval heart development GO:0007508
The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.
2 P11584 (/IMP) P11584 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
2 P11584 (/IMP) P11584 (/IMP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
2 P11584 (/IMP) P11584 (/IMP)
Regulation of G protein-coupled receptor signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
2 O54890 (/ISO) P09055 (/ISO)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 P11584 (/IMP) P11584 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 P11584 (/IMP) P11584 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O54890 (/IMP) P26012 (/IMP)
Regulation of collagen catabolic process GO:0010710
Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
2 P05556 (/IDA) P05556 (/IDA)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
2 P11584 (/IMP) P11584 (/IMP)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
2 P11584 (/TAS) P11584 (/TAS)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
2 P11584 (/TAS) P11584 (/TAS)
Calcium-dependent cell-matrix adhesion GO:0016340
The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.
2 P11584 (/ISS) P11584 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 B3DHB6 (/IMP) Q3YAA0 (/IMP)
Central nervous system morphogenesis GO:0021551
The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2 P11584 (/IMP) P11584 (/IMP)
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
2 P05556 (/ISS) P05556 (/ISS)
Lamellipodium assembly GO:0030032
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
2 P05556 (/ISS) P05556 (/ISS)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
2 P05556 (/IC) P05556 (/IC)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 O54890 (/IMP) P49134 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
2 P11584 (/IMP) P11584 (/IMP)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
2 P11584 (/IMP) P11584 (/IMP)
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
2 O54890 (/ISO) P09055 (/ISO)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
2 P09055 (/IDA) P11835 (/IDA)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 O54890 (/IMP) Q27874 (/IMP)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
2 P11584 (/IMP) P11584 (/IMP)
Cell-cell adhesion mediated by integrin GO:0033631
The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
2 P05556 (/IEP) P05556 (/IEP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
2 O54890 (/ISO) P26011 (/ISO)
Dorsal trunk growth, open tracheal system GO:0035001
Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.
2 P11584 (/IMP) P11584 (/IMP)
Hemocyte migration GO:0035099
The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.
2 P11584 (/IGI) P11584 (/IGI)
Maintenance of epithelial integrity, open tracheal system GO:0035160
Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.
2 P11584 (/IMP) P11584 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
2 B3DHB6 (/IMP) Q3YAA0 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 P05556 (/IGI) P05556 (/IGI)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
2 P05107 (/IMP) P26010 (/IMP)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
2 P11835 (/ISO) P26011 (/ISO)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
2 O54890 (/IGI) P05106 (/IGI)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
2 P05556 (/IMP) P05556 (/IMP)
Cellular extravasation GO:0045123
The migration of a leukocyte from the blood vessels into the surrounding tissue.
2 B2RYB8 (/IMP) P11835 (/IMP)
Imaginal disc-derived male genitalia morphogenesis GO:0048803
The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc.
2 P11584 (/IMP) P11584 (/IMP)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P05106 (/IMP) P49134 (/IMP)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 O54890 (/ISO) P09055 (/ISO)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
2 A8DSD5 (/IMP) P53714 (/IMP)
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
2 P09055 (/ISO) P26011 (/ISO)
Regulation of stress fiber assembly GO:0051492
Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
2 P11584 (/IMP) P11584 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 P05556 (/IDA) P05556 (/IDA)
Cardiac muscle cell development GO:0055013
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
2 B3DHB6 (/IGI) Q3YAA0 (/IGI)
Cardiac muscle cell development GO:0055013
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
2 B3DHB6 (/IMP) Q3YAA0 (/IMP)
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
2 B3DHB6 (/IMP) Q3YAA0 (/IMP)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
2 P09055 (/IDA) P11835 (/IDA)
Positive regulation of synapse maturation GO:0090129
Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
2 P11584 (/IMP) P11584 (/IMP)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
2 P18084 (/IMP) P18084 (/IMP)
Regulation of transforming growth factor beta activation GO:1901388
Any process that modulates the frequency, rate or extent of transforming growth factor beta activation.
2 P18564 (/IDA) Q0VBD0 (/IDA)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
2 P05556 (/IDA) P05556 (/IDA)
Positive regulation of signaling receptor activity GO:2000273
Any process that activates or increases the frequency, rate or extent of signaling receptor activity.
2 P05556 (/IDA) P05556 (/IDA)
Negative regulation of anoikis GO:2000811
Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
2 P05556 (/IMP) P05556 (/IMP)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
1 P09055 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 P26012 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q0VBD0 (/ISO)
Ganglioside metabolic process GO:0001573
The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
1 Q0VBD0 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P09055 (/IMP)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 P09055 (/IMP)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P05107 (/NAS)
Tissue homeostasis GO:0001894
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
1 P49134 (/IMP)
Tissue homeostasis GO:0001894
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
1 P09055 (/ISO)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P05106 (/TAS)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P05106 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 O54890 (/ISO)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 O54890 (/IMP)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 P09055 (/IMP)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
1 B2RYB8 (/IMP)
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
1 P11835 (/ISO)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P05106 (/TAS)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
1 O54890 (/ISO)
Cell-matrix adhesion involved in ameboidal cell migration GO:0003366
The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.
1 P26010 (/IMP)
Cell-matrix adhesion involved in ameboidal cell migration GO:0003366
The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.
1 P26011 (/ISO)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 P11835 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 P05107 (/ISS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P49134 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P09055 (/ISO)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
1 P11835 (/IMP)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
1 P05107 (/ISS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 P05107 (/NAS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q9Z0T9 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P05107 (/NAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q27874 (/IMP)
Cell-substrate junction assembly GO:0007044
The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
1 O54890 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P11835 (/IGI)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P11835 (/IMP)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 B2RYB8 (/IMP)
Calcium-independent cell-matrix adhesion GO:0007161
The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.
1 P09055 (/ISO)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O70309 (/ISO)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05106 (/HDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P11835 (/IDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05107 (/NAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 P05107 (/NAS)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 B2RYB8 (/IEP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P05106 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P09055 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P49134 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P09055 (/ISO)
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
1 P09055 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 P05107 (/NAS)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 P09055 (/IGI)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 P09055 (/IMP)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P05106 (/IMP)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 O54890 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q0VBD0 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P26012 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q0VBD0 (/ISO)
Regulation of collagen catabolic process GO:0010710
Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
1 P09055 (/ISO)
Negative regulation of macrophage derived foam cell differentiation GO:0010745
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 P05106 (/IMP)
Negative regulation of macrophage derived foam cell differentiation GO:0010745
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 O54890 (/ISO)
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
1 O54890 (/ISO)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 P49134 (/IMP)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 P09055 (/ISO)
Negative regulation of lipid storage GO:0010888
Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 P05106 (/IMP)
Negative regulation of lipid storage GO:0010888
Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 O54890 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P49134 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P09055 (/ISO)
Smooth muscle cell migration GO:0014909
The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.
1 P05106 (/IMP)
Smooth muscle cell migration GO:0014909
The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.
1 O54890 (/ISO)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 O54890 (/ISO)
Formation of radial glial scaffolds GO:0021943
The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells.
1 P09055 (/IMP)
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
1 P49134 (/IMP)
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
1 P09055 (/ISO)
Lamellipodium assembly GO:0030032
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
1 P49134 (/IMP)
Lamellipodium assembly GO:0030032
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
1 P09055 (/ISO)
Natural killer cell activation GO:0030101
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
1 B2RYB8 (/IMP)
Natural killer cell activation GO:0030101
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P11835 (/ISO)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
1 P05106 (/IMP)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
1 O54890 (/ISO)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 O54890 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P09055 (/ISO)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 P05107 (/IDA)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 P11835 (/IMP)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 P11835 (/ISO)
Positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
1 P05106 (/TAS)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P09055 (/IMP)
Negative regulation of cell projection organization GO:0031345
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
1 P49134 (/IMP)
Negative regulation of cell projection organization GO:0031345
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
1 P09055 (/ISO)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P49134 (/IEP)
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
1 P05106 (/IMP)
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
1 O54890 (/ISO)
Negative regulation of lipid transport GO:0032369
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P05106 (/IMP)
Negative regulation of lipid transport GO:0032369
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O54890 (/ISO)
Protein transport within lipid bilayer GO:0032594
The directed movement of a protein from one location to another within a lipid bilayer.
1 P49134 (/IMP)
Protein transport within lipid bilayer GO:0032594
The directed movement of a protein from one location to another within a lipid bilayer.
1 P09055 (/ISO)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 O54890 (/IMP)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
1 P05107 (/IGI)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
1 P11835 (/ISO)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
1 P05107 (/NAS)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 P49134 (/IGI)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
1 O54890 (/ISO)
Positive regulation of osteoblast proliferation GO:0033690
Any process that activates or increases the rate or extent of osteoblast proliferation.
1 O54890 (/IMP)
Toll-like receptor 4 signaling pathway GO:0034142
Any series of molecular signals generated as a consequence of binding to toll-like receptor 4.
1 P05107 (/TAS)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 P26010 (/IMP)
Response to gonadotropin GO:0034698
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
1 P49134 (/IEP)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
1 P09055 (/IGI)
Tube development GO:0035295
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
1 P05106 (/TAS)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
1 O54890 (/IMP)
Apolipoprotein A-I-mediated signaling pathway GO:0038027
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05106 (/IMP)
Apolipoprotein A-I-mediated signaling pathway GO:0038027
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O54890 (/ISO)
Transforming growth factor-beta secretion GO:0038044
The regulated release of transforming growth factor-beta (TGF-beta) from a cell into the extracellular region. TGF-beta is mostly secreted as a large latent TGF-beta complex (LLC) containing latency-associated proteins (LAPs) derived from the N-terminal region of the TGF-beta gene product, dimeric TGF-beta and latent TGF-beta binding proteins (LTBPs).
1 Q9Z0T9 (/IDA)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 Q27874 (/IMP)
Regulation of vulval development GO:0040028
Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 Q27874 (/IGI)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
1 Q27874 (/IMP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P05106 (/IC)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P49134 (/IEP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P09055 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P49134 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P09055 (/ISO)
Stress fiber assembly GO:0043149
The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.
1 O70309 (/ISO)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 O54890 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P05107 (/TAS)
Positive regulation of neutrophil degranulation GO:0043315
Any process that activates or increases the frequency, rate or extent of neutrophil degranulation.
1 P05107 (/IGI)
Positive regulation of neutrophil degranulation GO:0043315
Any process that activates or increases the frequency, rate or extent of neutrophil degranulation.
1 P11835 (/ISO)
Endothelial cell migration GO:0043542
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 B2RYB8 (/IMP)
Endothelial cell migration GO:0043542
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P11835 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 P09055 (/ISO)
Cellular extravasation GO:0045123
The migration of a leukocyte from the blood vessels into the surrounding tissue.
1 P11835 (/ISO)
Regulation of bone resorption GO:0045124
Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).
1 P05106 (/TAS)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 B2RYB8 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 P11835 (/ISO)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
1 P09055 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 P49134 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 P09055 (/ISO)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 P49134 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 P09055 (/ISO)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
1 O54890 (/IC)
Negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.
1 P05106 (/IMP)
Negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.
1 O54890 (/ISO)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 O54890 (/IC)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 O54890 (/ISO)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 P49134 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 P09055 (/ISO)
Negative regulation of dopamine metabolic process GO:0045963
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
1 P05107 (/NAS)
Positive regulation of smooth muscle contraction GO:0045987
Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
1 Q27874 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
1 Q27874 (/IMP)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 P05106 (/IMP)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 O54890 (/ISO)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
1 O54890 (/IMP)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05106 (/TAS)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 O54890 (/IMP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 O54890 (/ISO)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
1 P09055 (/IGI)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
1 P09055 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 P09055 (/IGI)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 P09055 (/IMP)
Cell projection morphogenesis GO:0048858
The process in which the anatomical structures of a cell projection are generated and organized.
1 O54890 (/IC)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P05107 (/IDA)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P11835 (/ISO)
Negative regulation of lipoprotein metabolic process GO:0050748
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.
1 P05106 (/IMP)
Negative regulation of lipoprotein metabolic process GO:0050748
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.
1 O54890 (/ISO)
Activated T cell proliferation GO:0050798
The expansion of a T cell population following activation by an antigenic stimulus.
1 P11835 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P09055 (/IMP)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 P26011 (/IMP)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 P05106 (/IMP)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 O54890 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 B2RYB8 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P11835 (/ISO)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 P26012 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 Q0VBD0 (/ISO)
Regulation of release of sequestered calcium ion into cytosol GO:0051279
Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
1 O54890 (/ISO)
Regulation of serotonin uptake GO:0051611
Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell.
1 O54890 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P09055 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 P09055 (/ISO)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
1 Q27874 (/IMP)
Striated muscle cell development GO:0055002
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
1 Q27874 (/IMP)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 P09055 (/IMP)
Angiogenesis involved in wound healing GO:0060055
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury.
1 P05106 (/TAS)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 P49134 (/IEP)
Positive regulation of ovulation GO:0060279
Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
1 Q27874 (/IMP)
Positive regulation of sarcomere organization GO:0060298
Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q27874 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 O54890 (/ISO)
Placenta blood vessel development GO:0060674
The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure.
1 P26012 (/TAS)
Regulation of protein tyrosine kinase activity GO:0061097
Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.
1 O54890 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 O54890 (/ISO)
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
1 O54890 (/ISO)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
1 P49134 (/IMP)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
1 P09055 (/ISO)
Cellular response to vitamin D GO:0071305
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
1 P49134 (/IEP)
Cellular response to ionizing radiation GO:0071479
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
1 P49134 (/IEP)
Response to transforming growth factor beta GO:0071559
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 P49134 (/IEP)
Basement membrane organization GO:0071711
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.
1 P09055 (/IMP)
Positive regulation of glomerular mesangial cell proliferation GO:0072126
Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.
1 O54890 (/ISO)
Vulval cell fate specification GO:0072327
The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes.
1 Q27874 (/IGI)
T cell migration GO:0072678
The movement of a T cell within or between different tissues and organs of the body.
1 P26011 (/IMP)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
1 O70309 (/ISO)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 P05107 (/NAS)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
1 P11835 (/IMP)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
1 P05107 (/ISS)
Establishment of Sertoli cell barrier GO:0097368
Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions.
1 P49134 (/IEP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P11835 (/IGI)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 B2RYB8 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P11835 (/ISO)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P05107 (/ISS)
Cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742
The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.
1 P05107 (/NAS)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 P05106 (/EXP)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 P05106 (/IDA)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 P05106 (/IMP)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 O54890 (/ISO)
Synaptic membrane adhesion to extracellular matrix GO:0099561
The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
1 P49134 (/IC)
Positive regulation of substrate adhesion-dependent cell spreading GO:1900026
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 O54890 (/IMP)
Positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway GO:1900731
Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway.
1 O54890 (/ISO)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 P05107 (/NAS)
Regulation of transforming growth factor beta activation GO:1901388
Any process that modulates the frequency, rate or extent of transforming growth factor beta activation.
1 Q9Z0T9 (/ISO)
Regulation of extracellular matrix organization GO:1903053
Any process that modulates the frequency, rate or extent of extracellular matrix organization.
1 O54890 (/IMP)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 P09055 (/ISO)
Regulation of distal tip cell migration GO:1903354
Any process that modulates the frequency, rate or extent of distal tip cell migration.
1 Q27874 (/IMP)
Positive regulation of distal tip cell migration GO:1903356
Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
1 Q27874 (/IMP)
Positive regulation of myosin II filament organization GO:1904901
Any process that activates or increases the frequency, rate or extent of myosin II filament organization.
1 Q27874 (/IMP)
Positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996
Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.
1 P11835 (/IMP)
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
1 P05107 (/IMP)
Neutrophil migration GO:1990266
The movement of a neutrophil within or between different tissues and organs of the body.
1 P11835 (/ISO)
Positive regulation of signaling receptor activity GO:2000273
Any process that activates or increases the frequency, rate or extent of signaling receptor activity.
1 P09055 (/ISO)
Positive regulation of prostaglandin-E synthase activity GO:2000363
Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity.
1 P05107 (/NAS)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
1 O54890 (/IDA)
Negative regulation of anoikis GO:2000811
Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
1 P09055 (/ISO)

There are 159 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
17 A0A0G2JWK0 (/IDA) B2RYB8 (/IDA) O54890 (/IDA) P05106 (/IDA) P05107 (/IDA) P05556 (/IDA) P05556 (/IDA) P09055 (/IDA) P11835 (/IDA) P18084 (/IDA)
(7 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
16 A5Z1X6 (/ISS) B0FYY4 (/ISS) P07228 (/ISS) P09055 (/ISS) P11584 (/ISS) P11584 (/ISS) P18563 (/ISS) P53712 (/ISS) P53713 (/ISS) Q1RPR6 (/ISS)
(6 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
15 O70309 (/TAS) P05106 (/TAS) P05107 (/TAS) P05556 (/TAS) P05556 (/TAS) P07228 (/TAS) P09055 (/TAS) P18084 (/TAS) P18084 (/TAS) P18564 (/TAS)
(5 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
12 F1N8N7 (/IDA) O54890 (/IDA) O70309 (/IDA) P05106 (/IDA) P05556 (/IDA) P05556 (/IDA) P07228 (/IDA) P11584 (/IDA) P11584 (/IDA) P18564 (/IDA)
(2 more)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
12 A5Z1X6 (/ISS) B0FYY4 (/ISS) P07228 (/ISS) P09055 (/ISS) P12606 (/ISS) P12606 (/ISS) P12607 (/ISS) P49134 (/ISS) P53712 (/ISS) P53713 (/ISS)
(2 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
11 A5Z1X6 (/ISS) B0FYY4 (/ISS) P32592 (/ISS) P53712 (/ISS) P53713 (/ISS) P53714 (/ISS) Q2VJ42 (/ISS) Q5RCA9 (/ISS) Q5VI41 (/ISS) Q6ECI6 (/ISS)
(1 more)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
9 A0A0G2JWK0 (/IDA) B3DIP9 (/IDA) P05106 (/IDA) P11584 (/IDA) P11584 (/IDA) P49134 (/IDA) Q3LTM5 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 A0A0G2JWK0 (/IDA) P09055 (/IDA) P11835 (/IDA) P49134 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA) Q9PUU4 (/IDA) W5UFK1 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
8 P05106 (/IDA) P05107 (/IDA) P05556 (/IDA) P05556 (/IDA) P18084 (/IDA) P18084 (/IDA) P18564 (/IDA) P26010 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 P05106 (/HDA) P05107 (/HDA) P05556 (/HDA) P05556 (/HDA) P18084 (/HDA) P18084 (/HDA) P26010 (/HDA) P26012 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 B2RYB8 (/IDA) P05106 (/IDA) P05556 (/IDA) P05556 (/IDA) P09055 (/IDA) P11584 (/IDA) P11584 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
7 A5Z1X6 (/ISS) B0FYY4 (/ISS) P07228 (/ISS) P53712 (/ISS) P53713 (/ISS) Q5RCA9 (/ISS) Q9GLP0 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 P05106 (/HDA) P05107 (/HDA) P05556 (/HDA) P05556 (/HDA) P18084 (/HDA) P18084 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 O54890 (/ISO) O70309 (/ISO) P09055 (/ISO) P11835 (/ISO) P26011 (/ISO) Q0VBD0 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 O54890 (/ISO) O70309 (/ISO) P09055 (/ISO) P11835 (/ISO) P26011 (/ISO) Q9Z0T9 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
5 P05106 (/HDA) P05556 (/HDA) P05556 (/HDA) P18084 (/HDA) P18084 (/HDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
5 P05107 (/NAS) P05556 (/NAS) P05556 (/NAS) P11584 (/NAS) P11584 (/NAS)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
5 P05106 (/TAS) P05107 (/TAS) P18564 (/TAS) P26010 (/TAS) P26012 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Integrin alphav-beta6 complex GO:0034685
An integrin complex that comprises one alphav subunit and one beta6 subunit.
5 P18563 (/ISS) Q1RPR6 (/ISS) Q6AYF4 (/ISS) Q863C4 (/ISS) Q8SQB8 (/ISS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
5 O54890 (/IDA) O70309 (/IDA) P05106 (/IDA) P09055 (/IDA) P49134 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P05107 (/HDA) P05556 (/HDA) P05556 (/HDA) P26010 (/HDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 A0A0G2JWK0 (/IDA) O54890 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 P05556 (/IDA) P05556 (/IDA) P11835 (/IDA) P49134 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A0A087WXP3 (/IDA) E9PEE8 (/IDA) P18564 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
3 A0A087WXP3 (/IDA) E9PEE8 (/IDA) P18564 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O54890 (/ISO) P09055 (/ISO) P11835 (/ISO)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 O54890 (/ISO) P09055 (/ISO) Q9Z0T9 (/ISO)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
3 P11584 (/IPI) P11584 (/IPI) Q27874 (/IPI)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 O54890 (/IDA) P09055 (/IDA) Q9Z0T9 (/IDA)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
3 P11584 (/IDA) P11584 (/IDA) Q27874 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
3 A0A087WXP3 (/IDA) E9PEE8 (/IDA) P18564 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
3 O70309 (/IDA) P11584 (/IDA) P11584 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
3 P05556 (/IDA) P05556 (/IDA) P09055 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P05107 (/TAS) P05556 (/TAS) P05556 (/TAS)
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
3 P05556 (/IDA) P05556 (/IDA) P49134 (/IDA)
Integrin alphav-beta5 complex GO:0034684
An integrin complex that comprises one alphav subunit and one beta5 subunit.
3 O70309 (/IDA) P18084 (/IDA) P18084 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
3 P05556 (/IDA) P05556 (/IDA) P09055 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
3 P05106 (/ISS) Q8R2H2 (/ISS) Q8R2H2 (/ISS)
Integral component of synaptic membrane GO:0099699
The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O54890 (/IDA) O70309 (/IDA) P09055 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
2 P05556 (/TAS) P05556 (/TAS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
2 P49134 (/IDA) Q27874 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 F1N8N7 (/IDA) P07228 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P05556 (/IDA) P05556 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P11584 (/HDA) P11584 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P05556 (/NAS) P05556 (/NAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P11584 (/IDA) P11584 (/IDA)
Muscle tendon junction GO:0005927
A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.
2 P11584 (/IDA) P11584 (/IDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
2 O54890 (/ISO) P09055 (/ISO)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
2 P11584 (/ISS) P11584 (/ISS)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P11584 (/IDA) P11584 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 O54890 (/ISO) P09055 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
2 P05556 (/IDA) P05556 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P11584 (/IDA) P11584 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
2 P05556 (/NAS) P05556 (/NAS)
Integrin alpha1-beta1 complex GO:0034665
An integrin complex that comprises one alpha1 subunit and one beta1 subunit.
2 P05556 (/IDA) P05556 (/IDA)
Integrin alpha2-beta1 complex GO:0034666
An integrin complex that comprises one alpha2 subunit and one beta1 subunit.
2 P05556 (/IDA) P05556 (/IDA)
Integrin alpha8-beta1 complex GO:0034678
An integrin complex that comprises one alpha8 subunit and one beta1 subunit.
2 P05556 (/TAS) P05556 (/TAS)
Integrin alpha10-beta1 complex GO:0034680
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
2 P05556 (/IDA) P05556 (/IDA)
Integrin alpha11-beta1 complex GO:0034681
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
2 P05556 (/IDA) P05556 (/IDA)
Integrin alphav-beta6 complex GO:0034685
An integrin complex that comprises one alphav subunit and one beta6 subunit.
2 P18564 (/IDA) Q9Z0T9 (/IDA)
Integrin alphav-beta8 complex GO:0034686
An integrin complex that comprises one alphav subunit and one beta8 subunit.
2 P26012 (/IDA) Q0VBD0 (/IDA)
Alphav-beta3 integrin-PKCalpha complex GO:0035866
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
2 O54890 (/IDA) P05106 (/IDA)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
2 P11584 (/IMP) P11584 (/IMP)
Costamere GO:0043034
Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.
2 P11584 (/IDA) P11584 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2 P09055 (/IDA) P49134 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 O54890 (/IDA) P09055 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
2 P11584 (/IMP) P11584 (/IMP)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
2 P18084 (/TAS) P18084 (/TAS)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
2 P05556 (/IDA) P05556 (/IDA)
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
2 P05556 (/ISS) P05556 (/ISS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 O54890 (/ISO) P09055 (/ISO)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 P49134 (/IDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 P09055 (/ISO)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 P09055 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P05106 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O54890 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Z0T9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P09055 (/ISO)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q9Z0T9 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P05106 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P49134 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P09055 (/ISO)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
1 P49134 (/IDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
1 P09055 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P05107 (/NAS)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
1 P09055 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 O54890 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q27874 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 Q9Z0T9 (/ISO)
Hemidesmosome GO:0030056
A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.
1 P49134 (/IDA)
Hemidesmosome GO:0030056
A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.
1 P09055 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 P09055 (/ISO)
Platelet alpha granule membrane GO:0031092
The lipid bilayer surrounding the platelet alpha granule.
1 P05106 (/TAS)
Lamellipodium membrane GO:0031258
The portion of the plasma membrane surrounding a lamellipodium.
1 P05106 (/IDA)
Lamellipodium membrane GO:0031258
The portion of the plasma membrane surrounding a lamellipodium.
1 O54890 (/ISO)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
1 Q27874 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
1 P05106 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
1 O54890 (/ISO)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 P05106 (/IDA)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 O54890 (/ISO)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
1 P09055 (/ISO)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 P05106 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 O54890 (/ISO)
Integrin alpha1-beta1 complex GO:0034665
An integrin complex that comprises one alpha1 subunit and one beta1 subunit.
1 P09055 (/ISO)
Integrin alpha2-beta1 complex GO:0034666
An integrin complex that comprises one alpha2 subunit and one beta1 subunit.
1 P09055 (/ISO)
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
1 P09055 (/ISO)
Integrin alpha4-beta7 complex GO:0034669
An integrin complex that comprises one alpha4 subunit and one beta7 subunit.
1 P26010 (/IDA)
Integrin alpha4-beta7 complex GO:0034669
An integrin complex that comprises one alpha4 subunit and one beta7 subunit.
1 P26011 (/ISO)
Integrin alpha7-beta1 complex GO:0034677
An integrin complex that comprises one alpha7 subunit and one beta1 subunit.
1 P09055 (/IDA)
Integrin alpha7-beta1 complex GO:0034677
An integrin complex that comprises one alpha7 subunit and one beta1 subunit.
1 P09055 (/IPI)
Integrin alpha9-beta1 complex GO:0034679
An integrin complex that comprises one alpha9 subunit and one beta1 subunit.
1 P49134 (/IDA)
Integrin alpha9-beta1 complex GO:0034679
An integrin complex that comprises one alpha9 subunit and one beta1 subunit.
1 P09055 (/ISO)
Integrin alpha9-beta1 complex GO:0034679
An integrin complex that comprises one alpha9 subunit and one beta1 subunit.
1 O54890 (/TAS)
Integrin alpha10-beta1 complex GO:0034680
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
1 P09055 (/ISO)
Integrin alpha11-beta1 complex GO:0034681
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
1 P09055 (/ISO)
Integrin alphav-beta3 complex GO:0034683
An integrin complex that comprises one alphav subunit and one beta3 subunit.
1 P05106 (/IDA)
Integrin alphav-beta3 complex GO:0034683
An integrin complex that comprises one alphav subunit and one beta3 subunit.
1 O54890 (/ISO)
Integrin alphav-beta5 complex GO:0034684
An integrin complex that comprises one alphav subunit and one beta5 subunit.
1 O70309 (/ISO)
Integrin alphav-beta6 complex GO:0034685
An integrin complex that comprises one alphav subunit and one beta6 subunit.
1 Q9Z0T9 (/ISO)
Integrin alphav-beta8 complex GO:0034686
An integrin complex that comprises one alphav subunit and one beta8 subunit.
1 Q0VBD0 (/ISO)
Integrin alphav-beta8 complex GO:0034686
An integrin complex that comprises one alphav subunit and one beta8 subunit.
1 P26013 (/ISS)
Integrin alphaL-beta2 complex GO:0034687
An integrin complex that comprises one alphaL subunit and one beta2 subunit.
1 P05107 (/IDA)
Integrin alphaL-beta2 complex GO:0034687
An integrin complex that comprises one alphaL subunit and one beta2 subunit.
1 P11835 (/ISO)
Integrin alphaM-beta2 complex GO:0034688
An integrin complex that comprises one alphaM subunit and one beta2 subunit.
1 P11835 (/IMP)
Integrin alphaM-beta2 complex GO:0034688
An integrin complex that comprises one alphaM subunit and one beta2 subunit.
1 P05107 (/ISS)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P05107 (/TAS)
Myelin sheath abaxonal region GO:0035748
The region of the myelin sheath furthest from the axon.
1 P09055 (/IDA)
Alphav-beta3 integrin-PKCalpha complex GO:0035866
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
1 O54890 (/ISO)
Alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867
A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.
1 P05106 (/IDA)
Alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867
A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.
1 O54890 (/ISO)
Alphav-beta3 integrin-HMGB1 complex GO:0035868
A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein.
1 P05106 (/IDA)
Alphav-beta3 integrin-HMGB1 complex GO:0035868
A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein.
1 O54890 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P09055 (/ISO)
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
1 P05106 (/IDA)
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
1 O54890 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q27874 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q27874 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P09055 (/ISO)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 P05107 (/IDA)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 P11835 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P09055 (/ISO)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 P49134 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 P09055 (/ISO)
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
1 Q27874 (/IDA)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
1 P05107 (/TAS)
Alphav-beta3 integrin-vitronectin complex GO:0071062
A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin.
1 P05106 (/TAS)
Alpha9-beta1 integrin-ADAM8 complex GO:0071133
A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
1 O54890 (/IDA)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
1 P09055 (/ISO)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 P09055 (/IDA)
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
1 P49134 (/IDA)
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
1 P09055 (/ISO)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P09055 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P05106 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P05106 (/IMP)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P49134 (/IDA)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P09055 (/ISO)
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
1 P05107 (/TAS)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
1 P05107 (/HDA)