The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 9: NADPH--cytochrome P450 reductase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 27 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
NADPH-hemoprotein reductase activity GO:0003958
Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
|
2 | P00388 (/IDA) P16435 (/IDA) |
|
NADPH-hemoprotein reductase activity GO:0003958
Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
|
1 | P00388 (/IMP) |
|
NADPH-hemoprotein reductase activity GO:0003958
Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
|
1 | P37040 (/ISO) |
|
NADPH-hemoprotein reductase activity GO:0003958
Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
|
1 | P16435 (/TAS) |
|
Cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128
Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
|
1 | P00388 (/IDA) |
|
Cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128
Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
|
1 | P37040 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P16435 (/IPI) |
|
Nitric oxide dioxygenase activity GO:0008941
Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.
|
1 | P00388 (/IDA) |
|
Nitric oxide dioxygenase activity GO:0008941
Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.
|
1 | P37040 (/ISO) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
1 | P00388 (/IDA) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
1 | P37040 (/ISO) |
|
FMN binding GO:0010181
Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
1 | P00388 (/IMP) |
|
FMN binding GO:0010181
Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
1 | P37040 (/ISO) |
|
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
|
1 | P37040 (/IMP) |
|
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
|
1 | P00388 (/IDA) |
|
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
|
1 | P37040 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P00388 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P00388 (/IMP) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P00388 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P37040 (/ISO) |
|
Iron-cytochrome-c reductase activity GO:0047726
Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+.
|
1 | P00388 (/IDA) |
|
Iron-cytochrome-c reductase activity GO:0047726
Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+.
|
1 | P37040 (/ISO) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | P00388 (/IMP) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | P37040 (/ISO) |
|
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
|
1 | P00388 (/IDA) |
|
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
|
1 | P00388 (/IMP) |
|
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
|
1 | P37040 (/ISO) |
There are 46 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cuticle hydrocarbon biosynthetic process GO:0006723
The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
|
2 | Q27597 (/IMP) Q27597 (/IMP) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
2 | P00388 (/IDA) P16435 (/IDA) |
|
Cytochrome c metabolic process GO:1903606
The chemical reactions and pathways involving cytochrome c.
|
2 | E1AVU6 (/IDA) F1P2T2 (/IDA) |
|
Regulation of growth plate cartilage chondrocyte proliferation GO:0003420
Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
|
1 | P00388 (/IMP) |
|
Regulation of growth plate cartilage chondrocyte proliferation GO:0003420
Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
|
1 | P37040 (/ISO) |
|
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
1 | P16435 (/TAS) |
|
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
1 | P00388 (/IEP) |
|
Carnitine metabolic process GO:0009437
The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
|
1 | P00388 (/IEP) |
|
Flavonoid metabolic process GO:0009812
The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins.
|
1 | P00388 (/IEP) |
|
Internal peptidyl-lysine acetylation GO:0018393
The addition of an acetyl group to a non-terminal lysine residue in a protein.
|
1 | P00388 (/IDA) |
|
Internal peptidyl-lysine acetylation GO:0018393
The addition of an acetyl group to a non-terminal lysine residue in a protein.
|
1 | P37040 (/ISO) |
|
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
|
1 | P00388 (/IDA) |
|
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
|
1 | P37040 (/ISO) |
|
Positive regulation of chondrocyte differentiation GO:0032332
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
|
1 | P00388 (/IMP) |
|
Positive regulation of chondrocyte differentiation GO:0032332
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
|
1 | P37040 (/ISO) |
|
Positive regulation of monooxygenase activity GO:0032770
Any process that activates or increases the activity of a monooxygenase.
|
1 | P16435 (/IDA) |
|
Positive regulation of monooxygenase activity GO:0032770
Any process that activates or increases the activity of a monooxygenase.
|
1 | P37040 (/ISO) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P00388 (/IEP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P00388 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P37040 (/ISO) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | P00388 (/IMP) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | P37040 (/ISO) |
|
Nitrate catabolic process GO:0043602
The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid.
|
1 | P00388 (/IDA) |
|
Nitrate catabolic process GO:0043602
The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid.
|
1 | P37040 (/ISO) |
|
Positive regulation of cholesterol biosynthetic process GO:0045542
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
1 | P00388 (/IMP) |
|
Positive regulation of cholesterol biosynthetic process GO:0045542
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
1 | P37040 (/ISO) |
|
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
|
1 | P00388 (/IMP) |
|
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
|
1 | P37040 (/ISO) |
|
Nitric oxide catabolic process GO:0046210
The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
1 | P00388 (/IDA) |
|
Nitric oxide catabolic process GO:0046210
The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
1 | P00388 (/IMP) |
|
Nitric oxide catabolic process GO:0046210
The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
1 | P37040 (/ISO) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | P37040 (/ISO) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | P16435 (/TAS) |
|
Negative regulation of lipase activity GO:0060192
Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.
|
1 | P00388 (/IDA) |
|
Negative regulation of lipase activity GO:0060192
Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.
|
1 | P37040 (/ISO) |
|
Demethylation GO:0070988
The process of removing one or more methyl groups from a molecule.
|
1 | P00388 (/IDA) |
|
Demethylation GO:0070988
The process of removing one or more methyl groups from a molecule.
|
1 | P37040 (/ISO) |
|
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
|
1 | P00388 (/IEP) |
|
Cellular response to follicle-stimulating hormone stimulus GO:0071372
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
|
1 | P00388 (/IEP) |
|
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | P00388 (/IEP) |
|
Positive regulation of steroid hormone biosynthetic process GO:0090031
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.
|
1 | P00388 (/IDA) |
|
Positive regulation of steroid hormone biosynthetic process GO:0090031
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.
|
1 | P37040 (/ISO) |
|
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P00388 (/IMP) |
|
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P37040 (/ISO) |
|
Cellular organofluorine metabolic process GO:0090346
The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.
|
1 | P16435 (/IDA) |
|
Cellular organofluorine metabolic process GO:0090346
The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.
|
1 | P37040 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
|
2 | Q27597 (/HDA) Q27597 (/HDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P00388 (/IDA) P16435 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P00388 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P37040 (/ISO) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | P16435 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P16435 (/HDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P00388 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P37040 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | P37040 (/ISO) |
