The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 942: Ras-related and estrogen-regulated growth inhibito...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
15 Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA)
(5 more)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
15 Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS) Q96A58 (/TAS)
(5 more)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
15 Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS)
(5 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q8R367 (/ISO)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
15 Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS) Q96A58 (/NAS)
(5 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
15 Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA)
(5 more)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
15 Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA)
(5 more)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
15 Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA)
(5 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8R367 (/ISO)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 Q8R367 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q8R367 (/ISO)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA) Q96A58 (/IDA)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8R367 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8R367 (/ISO)
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