The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 8: ATP-dependent RNA helicase RhlB
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 103 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
173 |
B5BTY4 (/IPI)
M9PBB5 (/IPI)
M9PBB5 (/IPI)
O00571 (/IPI)
O00571 (/IPI)
O00571 (/IPI)
O00571 (/IPI)
O00571 (/IPI)
O00571 (/IPI)
O00571 (/IPI)
(163 more) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
131 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(121 more) |
|
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
|
110 |
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
P0A8J8 (/IPI)
(100 more) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
43 |
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
(33 more) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
33 |
P06634 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(23 more) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
33 |
A5A6J2 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
(23 more) |
|
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
|
32 |
M9PBB5 (/IDA)
M9PBB5 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(22 more) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
31 |
A5A6J2 (/ISS)
O76743 (/ISS)
P24782 (/ISS)
P24784 (/ISS)
P24784 (/ISS)
P24784 (/ISS)
P24784 (/ISS)
Q4R6M5 (/ISS)
Q54QS3 (/ISS)
Q5R4I9 (/ISS)
(21 more) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
30 |
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
(20 more) |
|
MH2 domain binding GO:0035500
Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.
|
30 |
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
(20 more) |
|
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
30 |
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
(20 more) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
30 |
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
P17844 (/IPI)
(20 more) |
|
Primary miRNA binding GO:0070878
Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
19 |
Q7K4L8 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
(9 more) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
17 |
M9PBB5 (/TAS)
M9PBB5 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(7 more) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
15 |
M9PBB5 (/IDA)
M9PBB5 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(5 more) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
13 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(3 more) |
|
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
|
13 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(3 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Eukaryotic initiation factor 4E binding GO:0008190
Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
12 |
Q3MSQ8 (/ISS)
Q4R5S7 (/ISS)
Q5W5U4 (/ISS)
Q62167 (/ISS)
Q62167 (/ISS)
Q64060 (/ISS)
Q6GWX0 (/ISS)
Q91372 (/ISS)
Q91372 (/ISS)
Q9NQI0 (/ISS)
(2 more) |
|
Nucleoside-triphosphatase activity GO:0017111
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
CTPase activity GO:0043273
Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Protein serine/threonine kinase activator activity GO:0043539
Binds to and increases the activity of a protein serine/threonine kinase.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
12 |
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
(2 more) |
|
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
|
11 |
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
Q8IL13 (/ISS)
(1 more) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
11 |
Q388E8 (/IDA)
Q38DF6 (/IDA)
Q38DF6 (/IDA)
Q580H2 (/IDA)
Q580H2 (/IDA)
Q8LA13 (/IDA)
Q8LA13 (/IDA)
Q8W4R3 (/IDA)
Q8W4R3 (/IDA)
Q9M2F9 (/IDA)
(1 more) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
7 | Q10202 (/ISM) Q26696 (/ISM) Q388E8 (/ISM) Q38DF6 (/ISM) Q38DF6 (/ISM) Q580H2 (/ISM) Q580H2 (/ISM) |
|
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
6 | Q26696 (/ISM) Q388E8 (/ISM) Q38DF6 (/ISM) Q38DF6 (/ISM) Q580H2 (/ISM) Q580H2 (/ISM) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
5 | Q54CE0 (/ISS) Q62167 (/ISS) Q62167 (/ISS) Q8I5E7 (/ISS) Q8I5E7 (/ISS) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
5 | P06634 (/HDA) P24784 (/HDA) P24784 (/HDA) P24784 (/HDA) P24784 (/HDA) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
|
4 | Q10202 (/ISO) Q61656 (/ISO) Q62167 (/ISO) Q62167 (/ISO) |
|
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
RNA-dependent ATPase activity GO:0008186
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
|
4 | D0PV95 (/IDA) P20447 (/IDA) P20447 (/IDA) P24783 (/IDA) |
|
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
|
4 | O01836 (/IPI) O76743 (/IPI) P34689 (/IPI) Q966L9 (/IPI) |
|
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
3 | Q6AYI1 (/IDA) Q6AYI1 (/IDA) Q6AYI1 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
3 | Q6AYI1 (/IDA) Q6AYI1 (/IDA) Q6AYI1 (/IDA) |
|
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
3 | O01836 (/IPI) P34689 (/IPI) Q966L9 (/IPI) |
|
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
3 | Q6AYI1 (/IDA) Q6AYI1 (/IDA) Q6AYI1 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q92841 (/TAS) Q9NXZ2 (/TAS) |
|
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Eukaryotic initiation factor 4E binding GO:0008190
Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Eukaryotic initiation factor 4E binding GO:0008190
Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Nucleoside-triphosphatase activity GO:0017111
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
|
2 | O01836 (/IPI) P34689 (/IPI) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
RNA stem-loop binding GO:0035613
Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
CTPase activity GO:0043273
Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Protein serine/threonine kinase activator activity GO:0043539
Binds to and increases the activity of a protein serine/threonine kinase.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Protein serine/threonine kinase activator activity GO:0043539
Binds to and increases the activity of a protein serine/threonine kinase.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
1 | Q61656 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q92841 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q501J6 (/ISO) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
1 | P19109 (/ISS) |
|
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
|
1 | Q61656 (/ISO) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
1 | O13370 (/IMP) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
1 | Q61656 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | P24782 (/ISS) |
|
RNA-dependent ATPase activity GO:0008186
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
|
1 | P24783 (/IMP) |
|
RNA-dependent ATPase activity GO:0008186
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
|
1 | Q92841 (/TAS) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q61496 (/IMP) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | Q61656 (/ISO) |
|
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
|
1 | D0PV95 (/IMP) |
|
MH2 domain binding GO:0035500
Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.
|
1 | Q61656 (/ISO) |
|
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
|
1 | Q61656 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | D0PV95 (/IMP) |
|
Ribonucleoprotein complex binding GO:0043021
Interacting selectively and non-covalently with any complex of RNA and protein.
|
1 | Q61656 (/ISO) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
1 | Q61656 (/ISO) |
|
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
1 | Q61656 (/ISO) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | Q61656 (/ISO) |
|
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
|
1 | Q61656 (/ISO) |
|
Primary miRNA binding GO:0070878
Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
|
1 | Q61656 (/ISO) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
1 | Q61656 (/IDA) |
There are 230 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
|
110 |
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
P0A8J8 (/IMP)
(100 more) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
34 |
A5A6J2 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
(24 more) |
|
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
|
34 |
A5A6J2 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
(24 more) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
33 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(23 more) |
|
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
|
33 |
A5A6J2 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
(23 more) |
|
Pri-miRNA transcription by RNA polymerase II GO:0061614
The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation.
|
33 |
A5A6J2 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
P17844 (/ISS)
(23 more) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
32 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(22 more) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
31 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(21 more) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
31 |
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
P17844 (/IC)
(21 more) |
|
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
31 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(21 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
31 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(21 more) |
|
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
|
31 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(21 more) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
31 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(21 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
30 |
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
(20 more) |
|
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
MRNA transcription GO:0009299
The cellular synthesis of messenger RNA (mRNA) from a DNA template.
|
30 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(20 more) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
30 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(20 more) |
|
Positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517
Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
30 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(20 more) |
|
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
30 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(20 more) |
|
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
30 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(20 more) |
|
Positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800
Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
|
30 |
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
P17844 (/IMP)
(20 more) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
17 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(7 more) |
|
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
|
15 |
A1L1Z2 (/IMP)
E7EZA2 (/IMP)
F1QSP5 (/IMP)
F1R6M3 (/IMP)
F8W3U8 (/IMP)
F8W4P0 (/IMP)
O42107 (/IMP)
O42378 (/IMP)
P34689 (/IMP)
Q65XX1 (/IMP)
(5 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
13 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(3 more) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Negative regulation of protein complex assembly GO:0031333
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
12 |
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(2 more) |
|
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
12 |
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(2 more) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Positive regulation of translational initiation GO:0045948
Any process that activates or increases the frequency, rate or extent of translational initiation.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651
Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.
|
12 |
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(2 more) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
12 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(2 more) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
|
12 |
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(2 more) |
|
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
Male meiosis I GO:0007141
A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
|
10 | A1L1Z2 (/IEP) E7EZA2 (/IEP) F1QSP5 (/IEP) F1R6M3 (/IEP) F8W3U8 (/IEP) F8W4P0 (/IEP) O42107 (/IEP) O42378 (/IEP) Q8QFU0 (/IEP) Q8QGG8 (/IEP) |
|
Negative regulation of transposition GO:0010529
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
Regulation of meiotic cell cycle GO:0051445
Any process that modulates the rate or extent of progression through the meiotic cell cycle.
|
10 | A1L1Z2 (/IMP) E7EZA2 (/IMP) F1QSP5 (/IMP) F1R6M3 (/IMP) F8W3U8 (/IMP) F8W4P0 (/IMP) O42107 (/IMP) O42378 (/IMP) Q8QFU0 (/IMP) Q8QGG8 (/IMP) |
|
PiRNA biosynthetic process GO:1990511
The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
|
8 | Q9KV52 (/ISS) Q9KV52 (/ISS) Q9KV52 (/ISS) Q9KV52 (/ISS) Q9KV52 (/ISS) Q9KV52 (/ISS) Q9KV52 (/ISS) Q9KV52 (/ISS) |
|
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
|
6 | Q26696 (/ISM) Q388E8 (/ISM) Q38DF6 (/ISM) Q38DF6 (/ISM) Q580H2 (/ISM) Q580H2 (/ISM) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
5 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q501J6 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
5 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q501J6 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q501J6 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
5 | P16381 (/IMP) P16381 (/IMP) Q61496 (/IMP) Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
|
5 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q501J6 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
5 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q501J6 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
4 | M9PBB5 (/IMP) M9PBB5 (/IMP) P09052 (/IMP) P09052 (/IMP) |
|
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
|
4 | P34689 (/ISS) Q8I5E7 (/ISS) Q8I5E7 (/ISS) Q966L9 (/ISS) |
|
Positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517
Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
3 | F1RCB2 (/IMP) O42375 (/IMP) Q6PBB2 (/IMP) |
|
RNA interference GO:0016246
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
|
3 | P19109 (/IMP) Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
3 | Q9NQI0 (/IMP) Q9NQI0 (/IMP) Q9NQI0 (/IMP) |
|
Regulation of viral genome replication GO:0045069
Any process that modulates the frequency, rate or extent of viral genome replication.
|
3 | Q6AYI1 (/IMP) Q6AYI1 (/IMP) Q6AYI1 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q501J6 (/ISO) Q62167 (/ISO) Q62167 (/ISO) |
|
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
|
2 | Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
|
2 | Q501J6 (/ISO) Q61656 (/ISO) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
2 | Q501J6 (/ISO) Q61656 (/ISO) |
|
Endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000464
Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.
|
2 | P20447 (/IMP) P20447 (/IMP) |
|
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q501J6 (/ISO) Q61656 (/ISO) |
|
Instar larval development GO:0002168
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
|
2 | Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q501J6 (/ISO) Q61656 (/ISO) |
|
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
|
2 | P24782 (/ISO) Q10202 (/ISO) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
|
2 | M9PBB5 (/IMP) M9PBB5 (/IMP) |
|
Germarium-derived egg chamber formation GO:0007293
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
|
2 | M9PBB5 (/IMP) M9PBB5 (/IMP) |
|
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
|
2 | M9PBB5 (/NAS) M9PBB5 (/NAS) |
|
Pole plasm assembly GO:0007315
Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.
|
2 | M9PBB5 (/IMP) M9PBB5 (/IMP) |
|
Pole plasm assembly GO:0007315
Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Pole plasm RNA localization GO:0007316
Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
|
2 | M9PBB5 (/IMP) M9PBB5 (/IMP) |
|
Intracellular mRNA localization GO:0008298
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
|
2 | P34689 (/IMP) Q966L9 (/IMP) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
|
2 | Q501J6 (/ISO) Q61656 (/ISO) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
2 | Q501J6 (/ISO) Q61656 (/ISO) |
|
Oocyte karyosome formation GO:0030717
The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
|
2 | M9PBB5 (/NAS) M9PBB5 (/NAS) |
|
Negative regulation of protein complex assembly GO:0031333
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Negative regulation of protein complex assembly GO:0031333
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072
Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis.
|
2 | Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Male germ-line stem cell population maintenance GO:0036098
The process by which an organism or tissue maintains a population of male germ-line stem cells.
|
2 | Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
|
2 | D0PV95 (/IGI) Q65XX1 (/IGI) |
|
Masculinization of hermaphroditic germ-line GO:0042006
The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans.
|
2 | D0PV95 (/IGI) Q65XX1 (/IGI) |
|
Masculinization of hermaphroditic germ-line GO:0042006
The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans.
|
2 | D0PV95 (/IMP) Q65XX1 (/IMP) |
|
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Negative regulation by host of viral genome replication GO:0044828
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication.
|
2 | F1RX16 (/IMP) F4ZS18 (/IMP) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
2 | Q501J6 (/IMP) Q61656 (/IMP) |
|
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | M9PBB5 (/IMP) M9PBB5 (/IMP) |
|
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | F1RX16 (/IMP) F4ZS18 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of translational initiation GO:0045948
Any process that activates or increases the frequency, rate or extent of translational initiation.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of translational initiation GO:0045948
Any process that activates or increases the frequency, rate or extent of translational initiation.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Regulation of oskar mRNA translation GO:0046011
Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Positive regulation of oskar mRNA translation GO:0046012
Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.
|
2 | M9PBB5 (/NAS) M9PBB5 (/NAS) |
|
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
|
2 | M9PBB5 (/HMP) M9PBB5 (/HMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
2 | M9PBB5 (/HMP) M9PBB5 (/HMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
2 | Q9VHP0 (/IMP) Q9VHP0 (/IMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Pri-miRNA transcription by RNA polymerase II GO:0061614
The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation.
|
2 | Q501J6 (/IMP) Q61656 (/IMP) |
|
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Positive regulation of fertilization GO:1905516
Any process that activates or increases the frequency, rate or extent of fertilization.
|
2 | D0PV95 (/IGI) Q65XX1 (/IGI) |
|
Positive regulation of fertilization GO:1905516
Any process that activates or increases the frequency, rate or extent of fertilization.
|
2 | D0PV95 (/IMP) Q65XX1 (/IMP) |
|
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
|
2 | Q61656 (/IMP) Q92841 (/IMP) |
|
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
|
2 | Q62167 (/ISO) Q62167 (/ISO) |
|
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q61656 (/ISO) |
|
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
|
1 | P24783 (/IPI) |
|
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
|
1 | P24782 (/ISO) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
1 | P19109 (/HMP) |
|
Spliceosomal complex disassembly GO:0000390
Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.
|
1 | P06634 (/IDA) |
|
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
|
1 | Q61656 (/ISO) |
|
Cytoplasmic translational initiation GO:0002183
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | O13370 (/IMP) |
|
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
|
1 | P24783 (/IMP) |
|
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
|
1 | Q92841 (/TAS) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
1 | Q61656 (/IGI) |
|
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
|
1 | Q61496 (/IMP) |
|
Male meiosis I GO:0007141
A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.
|
1 | Q61496 (/IMP) |
|
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
|
1 | O76743 (/IMP) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q64060 (/IEP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | Q61656 (/IMP) |
|
MRNA transcription GO:0009299
The cellular synthesis of messenger RNA (mRNA) from a DNA template.
|
1 | Q61656 (/ISO) |
|
Negative regulation of transposition GO:0010529
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
|
1 | Q61496 (/IMP) |
|
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
1 | Q92841 (/IMP) |
|
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
1 | Q501J6 (/ISO) |
|
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
1 | Q501J6 (/ISS) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | D0PV95 (/IMP) |
|
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
|
1 | P19109 (/IMP) |
|
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
1 | Q61496 (/ISO) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q61656 (/ISO) |
|
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
|
1 | O13370 (/IDA) |
|
Pre-miRNA processing GO:0031054
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
|
1 | Q9XUW5 (/IMP) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q61496 (/IMP) |
|
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
|
1 | Q61496 (/IMP) |
|
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
|
1 | D0PV95 (/IMP) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | O76743 (/IMP) |
|
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
|
1 | Q61496 (/IMP) |
|
Positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517
Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
1 | Q61656 (/ISO) |
|
Regulation of viral genome replication GO:0045069
Any process that modulates the frequency, rate or extent of viral genome replication.
|
1 | Q61656 (/ISO) |
|
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
|
1 | Q61656 (/IMP) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
1 | Q9W3M7 (/IGI) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q61656 (/IDA) |
|
Regulation of defense response to virus GO:0050688
Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
|
1 | P19109 (/IMP) |
|
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
1 | Q61656 (/ISO) |
|
Nuclear polyadenylation-dependent mRNA catabolic process GO:0071042
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.
|
1 | P24783 (/IGI) |
|
Nuclear polyadenylation-dependent mRNA catabolic process GO:0071042
The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.
|
1 | P24783 (/IMP) |
|
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
1 | Q61656 (/ISO) |
|
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
|
1 | C8V8H4 (/IEP) |
|
Positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800
Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
|
1 | Q61656 (/ISO) |
|
Messenger ribonucleoprotein complex assembly GO:1990120
The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex.
|
1 | P24783 (/IMP) |
|
PiRNA biosynthetic process GO:1990511
The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
|
1 | Q61496 (/IMP) |
|
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
|
1 | Q501J6 (/ISO) |
There are 71 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
135 |
A0A024R9A4 (/IDA)
A0A024R9A4 (/IDA)
A0A0D9SF53 (/IDA)
A0A0D9SFB3 (/IDA)
A0A0D9SFB3 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(125 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
60 |
A0A024R9A4 (/IDA)
A0A024R9A4 (/IDA)
A0A0D9SF53 (/IDA)
A0A0D9SFB3 (/IDA)
A0A0D9SFB3 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(50 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
42 |
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
O00571 (/HDA)
(32 more) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
37 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(27 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
36 |
D0PV95 (/IDA)
M9PBB5 (/IDA)
M9PBB5 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(26 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
33 |
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
(23 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
33 |
O15523 (/HDA)
O15523 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
P17844 (/HDA)
(23 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
31 |
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
P17844 (/TAS)
(21 more) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
31 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(21 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
30 |
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
P17844 (/NAS)
(20 more) |
|
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
30 |
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
P17844 (/IDA)
(20 more) |
|
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
|
25 |
A1L1Z2 (/IDA)
D0PV95 (/IDA)
E7EZA2 (/IDA)
F1QSP5 (/IDA)
F1R6M3 (/IDA)
F8W3U8 (/IDA)
F8W4P0 (/IDA)
M9PBB5 (/IDA)
M9PBB5 (/IDA)
O01836 (/IDA)
(15 more) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
15 |
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
O00571 (/IDA)
(5 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
14 |
F1RX16 (/IMP)
F4ZS18 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
O00571 (/IMP)
(4 more) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
12 |
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(2 more) |
|
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
|
12 |
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(2 more) |
|
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
|
12 |
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
O00571 (/TAS)
(2 more) |
|
Pi-body GO:0071546
A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
PiP-body GO:0071547
A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.
|
10 | Q3MSQ8 (/ISS) Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) Q91372 (/ISS) Q91372 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) Q9NQI0 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q54CE0 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) Q62167 (/ISS) Q62167 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | Q4Q5P5 (/ISO) Q501J6 (/ISO) Q61656 (/ISO) Q62095 (/ISO) Q62167 (/ISO) Q62167 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | P19109 (/HDA) P24783 (/HDA) P24784 (/HDA) P24784 (/HDA) P24784 (/HDA) P24784 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | Q4R5S7 (/ISS) Q5W5U4 (/ISS) Q62167 (/ISS) Q62167 (/ISS) Q64060 (/ISS) Q6GWX0 (/ISS) |
|
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
|
5 | B2C6E9 (/IDA) Q5W5U4 (/IDA) Q61496 (/IDA) Q64060 (/IDA) Q6GWX0 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
4 | A5A6J2 (/ISS) Q4R6M5 (/ISS) Q5R4I9 (/ISS) Q61656 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q4Q5P5 (/ISO) Q61496 (/ISO) Q62167 (/ISO) Q62167 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | O13370 (/HDA) P24782 (/HDA) Q9VHP0 (/HDA) Q9VHP0 (/HDA) |
|
Pole plasm GO:0045495
Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.
|
4 | M9PBB5 (/IDA) M9PBB5 (/IDA) Q91372 (/IDA) Q91372 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
4 | M9PBB5 (/IDA) M9PBB5 (/IDA) Q61496 (/IDA) Q64060 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
3 | Q4Q1K8 (/ISO) Q4QIQ9 (/ISO) Q61656 (/ISO) |
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
3 | Q84W89 (/IDA) Q8LA13 (/IDA) Q8LA13 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q62095 (/ISO) Q62167 (/ISO) Q62167 (/ISO) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
3 | Q4Q5P5 (/ISO) Q62167 (/ISO) Q62167 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P19109 (/IC) Q61656 (/IC) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
2 | Q91372 (/IDA) Q91372 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q580H2 (/IDA) Q580H2 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
2 | P24782 (/HDA) Q10202 (/HDA) |
|
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
|
2 | Q9SQV1 (/IDA) Q9SQV1 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q8LA13 (/IDA) Q8LA13 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
2 | Q62167 (/ISS) Q62167 (/ISS) |
|
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
|
2 | Q9VHP0 (/IDA) Q9VHP0 (/IDA) |
|
Preribosome, large subunit precursor GO:0030687
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
|
2 | P20447 (/IDA) P20447 (/IDA) |
|
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
2 | M9PBB5 (/IDA) M9PBB5 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | Q9VHP0 (/IDA) Q9VHP0 (/IDA) |
|
Germ cell nucleus GO:0043073
The nucleus of a germ cell, a reproductive cell in multicellular organisms.
|
2 | P09052 (/IDA) P09052 (/IDA) |
|
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
|
2 | M9PBB5 (/TAS) M9PBB5 (/TAS) |
|
Spectrosome GO:0045170
A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome.
|
2 | M9PBB5 (/IDA) M9PBB5 (/IDA) |
|
Posterior cell cortex GO:0061803
The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis.
|
2 | P09052 (/IDA) P09052 (/IDA) |
|
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
1 | Q9NXZ2 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q92841 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q4QIQ9 (/ISO) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
1 | P19109 (/IDA) |
|
Polytene chromosome puff GO:0005703
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
|
1 | P19109 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O13370 (/EXP) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P06634 (/IC) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P24783 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q61496 (/TAS) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q92841 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q501J6 (/ISO) |
|
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
|
1 | Q61496 (/ISO) |
|
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
1 | Q388E8 (/IDA) |
|
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
1 | Q4Q5P5 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q61496 (/ISO) |
|
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
|
1 | P19109 (/HDA) |
|
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
1 | P19109 (/HDA) |
|
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
1 | Q61656 (/ISO) |
|
Pi-body GO:0071546
A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.
|
1 | Q61496 (/IDA) |
|
PiP-body GO:0071547
A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.
|
1 | Q61496 (/IDA) |
|
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q388E8 (/IDA) |
|
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q4Q5P5 (/ISO) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | Q61656 (/ISO) |
