The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 479: Multidrug resistance protein 1A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O70127 (/IPI) O70127 (/IPI) O70127 (/IPI) O70127 (/IPI) Q08201 (/IPI) Q08201 (/IPI)
Canalicular bile acid transmembrane transporter activity GO:0015126
The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
4 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
2 Q17645 (/ISS) Q17645 (/ISS)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
2 A0MH69 (/IMP) A0MH69 (/IMP)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
4 O70127 (/IEP) O70127 (/IEP) O70127 (/IEP) O70127 (/IEP)
Canalicular bile acid transport GO:0015722
Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
4 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA)
Positive regulation of cholesterol transport GO:0032376
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Bile acid secretion GO:0032782
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 Q08201 (/IEP) Q08201 (/IEP) Q17645 (/IEP) Q17645 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 O70127 (/IMP) O70127 (/IMP) O70127 (/IMP) O70127 (/IMP)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
4 O70127 (/IEP) O70127 (/IEP) O70127 (/IEP) O70127 (/IEP)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
4 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Positive regulation of phospholipid translocation GO:0061092
Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Response to fenofibrate GO:1901557
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Cellular response to bile acid GO:1903413
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Positive regulation of phospholipid transport GO:2001140
Any process that activates or increases the frequency, rate or extent of phospholipid transport.
4 P23174 (/ISS) P23174 (/ISS) Q08201 (/ISS) Q08201 (/ISS)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
2 Q24393 (/IEP) Q24393 (/IEP)
Bile acid secretion GO:0032782
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
2 A0A0R4IVE7 (/IMP) A0A0R4IVE7 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2 Q17645 (/IEP) Q17645 (/IEP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2 Q17645 (/IMP) Q17645 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 Q17645 (/IEP) Q17645 (/IEP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 Q17645 (/IMP) Q17645 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 Q08201 (/IEP) Q08201 (/IEP)
Response to nematicide GO:0093002
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes.
2 Q17645 (/IEP) Q17645 (/IEP)
Renal tubular secretion GO:0097254
Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.
2 Q24393 (/IEP) Q24393 (/IEP)
Stress response to copper ion GO:1990169
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus.
2 Q17645 (/IEP) Q17645 (/IEP)
Stress response to copper ion GO:1990169
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus.
2 Q17645 (/IMP) Q17645 (/IMP)
Stress response to cadmium ion GO:1990170
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus.
2 Q17645 (/IEP) Q17645 (/IEP)
Stress response to cadmium ion GO:1990170
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus.
2 Q17645 (/IMP) Q17645 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
6 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) Q08201 (/IDA) Q08201 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
6 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) Q08201 (/IDA) Q08201 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O70127 (/IDA) O70127 (/IDA) O70127 (/IDA) O70127 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P23174 (/ISS) P23174 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P23174 (/ISS) P23174 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q17645 (/ISS) Q17645 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P23174 (/ISS) P23174 (/ISS)
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