The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 473: Vacuolar sorting-associated 1 protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Membrane scission GTPase motor activity GO:1990606
Catalysis of the generation of a 'twisting' activity resulting in the scission of a membrane, coupled to the hydrolysis of a nucleoside triphosphate.
1 Q9URZ5 (/TAS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein targeting to vacuole GO:0006623
The process of directing proteins towards the vacuole, usually using signals contained within the protein.
9 A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
6 P21576 (/IGI) P21576 (/IGI) P21576 (/IGI) P21576 (/IGI) P21576 (/IGI) P21576 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
6 P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
6 P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Vacuolar transport GO:0007034
The directed movement of substances into, out of or within a vacuole.
6 P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Peroxisome fission GO:0016559
The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.
6 P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
6 P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Protein retention in Golgi apparatus GO:0045053
The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.
6 P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP) P21576 (/IMP)
Lipid tube assembly GO:0060988
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Protein targeting to vacuole GO:0006623
The process of directing proteins towards the vacuole, usually using signals contained within the protein.
3 A0A1D8PN45 (/IGI) A0A1D8PN45 (/IGI) A0A1D8PN45 (/IGI)
Vacuole organization GO:0007033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
3 G5EB49 (/IMP) G5EB49 (/IMP) G5EB49 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
3 A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP)
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
3 A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
3 A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP) A0A1D8PN45 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q9URZ5 (/ISO)
Peroxisome organization GO:0007031
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
1 Q9URZ5 (/IGI)
Vesicle scission GO:0099050
The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane.
1 Q9URZ5 (/NAS)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
6 P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA) P21576 (/HDA)
Actin cortical patch GO:0030479
An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
6 P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA) P21576 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9URZ5 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9URZ5 (/HDA)
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