The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 302: ATP-binding cassette subfamily B member 5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | P08183 (/IPI) P08183 (/IPI) P08183 (/IPI) P08183 (/IPI) P21439 (/IPI) P21439 (/IPI) Q6PSM0 (/IPI) Q6PSM0 (/IPI) |
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
6 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P21439 (/TAS) P21439 (/TAS) |
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
6 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P21439 (/IDA) P21439 (/IDA) |
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
|
4 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
4 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) |
Phosphatidylethanolamine flippase activity GO:0090555
Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
4 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) |
Ceramide floppase activity GO:0099038
Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
4 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) |
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
|
3 | E7F1E3 (/IMP) E7F1E3 (/IMP) Q5I1Z1 (/IMP) |
Phospholipid transporter activity GO:0005548
Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
|
2 | P21439 (/TAS) P21439 (/TAS) |
ATPase-coupled protein transmembrane transporter activity GO:0015462
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in).
|
2 | E7F1E3 (/IDA) E7F1E3 (/IDA) |
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
|
2 | Q2M3G0 (/IDA) Q2M3G0 (/IDA) |
Efflux transmembrane transporter activity GO:0015562
Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
|
2 | B5X0E4 (/ISO) B5X0E4 (/ISO) |
Toxin transmembrane transporter activity GO:0019534
Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
|
2 | E7F1E3 (/IDA) E7F1E3 (/IDA) |
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
2 | P21439 (/IDA) P21439 (/IDA) |
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
2 | P21439 (/IMP) P21439 (/IMP) |
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
|
2 | Q9SYI2 (/ISS) Q9SYI2 (/ISS) |
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
2 | P21439 (/IMP) P21439 (/IMP) |
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
|
1 | Q5I1Z1 (/IMP) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
8 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P21439 (/TAS) P21439 (/TAS) Q2M3G0 (/TAS) Q2M3G0 (/TAS) |
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
6 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P21439 (/IDA) P21439 (/IDA) |
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
|
4 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) |
Establishment of endothelial blood-brain barrier GO:0014045
Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
|
4 | P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
4 | P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
4 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) |
Regulation of response to osmotic stress GO:0047484
Any process that modulates the rate or extent of the response to osmotic stress.
|
4 | P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) |
Sertoli cell barrier remodeling GO:0061843
The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle.
|
4 | P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) |
Stem cell proliferation GO:0072089
The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
4 | P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) |
Ceramide translocation GO:0099040
The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
4 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) |
Positive regulation of anion channel activity GO:1901529
Any process that activates or increases the frequency, rate or extent of anion channel activity.
|
4 | P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) |
Regulation of chloride transport GO:2001225
Any process that modulates the frequency, rate or extent of chloride transport.
|
4 | P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) P08183 (/IMP) |
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
2 | P21439 (/TAS) P21439 (/TAS) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
2 | E7F1E3 (/IDA) E7F1E3 (/IDA) |
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
2 | P21439 (/TAS) P21439 (/TAS) |
Positive regulation of cholesterol transport GO:0032376
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Positive regulation of cholesterol transport GO:0032376
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P21439 (/IMP) P21439 (/IMP) |
Bile acid secretion GO:0032782
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
|
2 | P21439 (/ISS) P21439 (/ISS) |
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
2 | Q2M3G0 (/IDA) Q2M3G0 (/IDA) |
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
2 | B5X0E4 (/ISO) B5X0E4 (/ISO) |
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
2 | P21439 (/IMP) P21439 (/IMP) |
Compound eye corneal lens development GO:0048058
The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells.
|
2 | B5X0E4 (/IMP) B5X0E4 (/IMP) |
Compound eye corneal lens development GO:0048058
The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells.
|
2 | Q2M3G0 (/ISS) Q2M3G0 (/ISS) |
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
2 | Q2M3G0 (/IDA) Q2M3G0 (/IDA) |
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
2 | B5X0E4 (/ISO) B5X0E4 (/ISO) |
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Positive regulation of phospholipid translocation GO:0061092
Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Response to fenofibrate GO:1901557
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus.
|
2 | P21439 (/ISS) P21439 (/ISS) |
Cellular response to bile acid GO:1903413
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Positive regulation of phospholipid transport GO:2001140
Any process that activates or increases the frequency, rate or extent of phospholipid transport.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Positive regulation of phospholipid transport GO:2001140
Any process that activates or increases the frequency, rate or extent of phospholipid transport.
|
2 | P21439 (/IMP) P21439 (/IMP) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P21439 (/TAS) P21439 (/TAS) Q2M3G0 (/TAS) Q2M3G0 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
6 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P21439 (/TAS) P21439 (/TAS) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
6 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P21439 (/IDA) P21439 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
6 | P08183 (/HDA) P08183 (/HDA) P08183 (/HDA) P08183 (/HDA) P21439 (/HDA) P21439 (/HDA) |
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
4 | P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
4 | P06795 (/HDA) P06795 (/HDA) P06795 (/HDA) P06795 (/HDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | B5X0E4 (/IDA) B5X0E4 (/IDA) Q2M3G0 (/IDA) Q2M3G0 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
4 | P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) P08183 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) P08183 (/TAS) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
4 | P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) P06795 (/ISO) |
Intercellular canaliculus GO:0046581
An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
|
4 | P06795 (/IDA) P06795 (/IDA) P06795 (/IDA) P06795 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P21439 (/IDA) P21439 (/IDA) Q5I1Z1 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | B5X0E4 (/ISO) B5X0E4 (/ISO) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P21439 (/TAS) P21439 (/TAS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | P21439 (/IDA) P21439 (/IDA) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | P21439 (/IDA) P21439 (/IDA) |