The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 211: Elongation factor 1-alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI)
(3 more)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
10 P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
10 P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
10 P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI)
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
6 P0CY35 (/ISS) P0CY35 (/ISS) P0CY35 (/ISS) Q59QD6 (/ISS) Q59QD6 (/ISS) Q59QD6 (/ISS)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
5 P0CT53 (/ISO) P0CT54 (/ISO) P0CT54 (/ISO) P0CT55 (/ISO) P0CT55 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
5 P0CT53 (/IDA) P0CT54 (/IDA) P0CT54 (/IDA) P0CT55 (/IDA) P0CT55 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
10 P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI) P02994 (/IGI)
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
10 P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP)
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
10 P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
10 P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP) P02994 (/IMP)
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
6 P0CY35 (/ISS) P0CY35 (/ISS) P0CY35 (/ISS) Q59QD6 (/ISS) Q59QD6 (/ISS) Q59QD6 (/ISS)
Cytoplasmic translational elongation GO:0002182
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.
5 P0CT53 (/IDA) P0CT54 (/IDA) P0CT54 (/IDA) P0CT55 (/IDA) P0CT55 (/IDA)
Interaction with host GO:0051701
An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
3 P0CY35 (/IPI) P0CY35 (/IPI) P0CY35 (/IPI)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA) P02994 (/HDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
12 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
(2 more)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
10 P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA) P02994 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI) P02994 (/IPI)
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
10 P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS) P02994 (/TAS)
Eukaryotic translation elongation factor 1 complex GO:0005853
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.
10 P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS) P02994 (/ISS)
Yeast-form cell wall GO:0030445
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
6 P0CY35 (/IDA) P0CY35 (/IDA) P0CY35 (/IDA) Q59QD6 (/IDA) Q59QD6 (/IDA) Q59QD6 (/IDA)
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
6 P0CY35 (/IDA) P0CY35 (/IDA) P0CY35 (/IDA) Q59QD6 (/IDA) Q59QD6 (/IDA) Q59QD6 (/IDA)
Eukaryotic translation elongation factor 1 complex GO:0005853
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.
5 P0CT53 (/ISO) P0CT54 (/ISO) P0CT54 (/ISO) P0CT55 (/ISO) P0CT55 (/ISO)
Fungal-type cell wall GO:0009277
A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
3 P0CY35 (/IDA) P0CY35 (/IDA) P0CY35 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 P0CY35 (/IDA) P0CY35 (/IDA) P0CY35 (/IDA)
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