The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: Translation initiation factor IF-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
120 P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA)
(110 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
120 P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA)
(110 more)
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
118 P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA)
(108 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
117 P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI) P0A705 (/IPI)
(107 more)
Guanosine tetraphosphate binding GO:0097216
Interacting selectively and non-covalently with guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.
117 P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA)
(107 more)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
9 Q8MS23 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9VAV2 (/ISS)
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
3 P25038 (/IDA) P25038 (/IDA) P25038 (/IDA)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
3 P25038 (/ISA) P25038 (/ISA) P25038 (/ISA)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
3 P46199 (/ISS) Q68FQ5 (/ISS) Q91YJ5 (/ISS)
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
3 P46199 (/ISS) Q68FQ5 (/ISS) Q91YJ5 (/ISS)
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
2 Q8MS23 (/ISS) Q9VAV2 (/ISS)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2 F7FDM3 (/TAS) Q68FQ5 (/TAS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 Q8MS23 (/ISS) Q9VAV2 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 F7FDM3 (/TAS) Q68FQ5 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P46199 (/HDA)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
1 O59683 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 O59683 (/ISO)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
1 P46198 (/IDA)
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
1 P46199 (/TAS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
117 P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA)
(107 more)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
9 Q8MS23 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9KU80 (/ISS) Q9VAV2 (/ISS)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
6 Q9HV55 (/IMP) Q9HV55 (/IMP) Q9HV55 (/IMP) Q9HV55 (/IMP) Q9HV55 (/IMP) Q9HV55 (/IMP)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
3 P25038 (/ISA) P25038 (/ISA) P25038 (/ISA)
Mitochondrial translation GO:0032543
The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
3 P25038 (/IMP) P25038 (/IMP) P25038 (/IMP)
Ribosome disassembly GO:0032790
The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
3 P46199 (/ISS) Q68FQ5 (/ISS) Q91YJ5 (/ISS)
Mitochondrial translational initiation GO:0070124
The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
3 P25038 (/IC) P25038 (/IC) P25038 (/IC)
Mitochondrial translational initiation GO:0070124
The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
3 P46199 (/ISS) Q68FQ5 (/ISS) Q91YJ5 (/ISS)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
2 F7FDM3 (/TAS) Q68FQ5 (/TAS)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
2 F7FDM3 (/TAS) Q68FQ5 (/TAS)
Mitochondrial translation GO:0032543
The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
2 Q8MS23 (/ISS) Q9VAV2 (/ISS)
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
1 P46199 (/TAS)
Ribosome disassembly GO:0032790
The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
1 P46198 (/IDA)
Mitochondrial translational initiation GO:0070124
The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
1 P46198 (/IDA)
Mitochondrial translational initiation GO:0070124
The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
1 O59683 (/ISO)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
118 P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA) P0A705 (/IDA)
(108 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
117 P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA) P0A705 (/HDA)
(107 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
9 P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI) P9WKK1 (/IGI)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA) P9WKK1 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 O59683 (/HDA) P25038 (/HDA) P25038 (/HDA) P25038 (/HDA) Q91YJ5 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P25038 (/HDA) P25038 (/HDA) P25038 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P25038 (/IMP) P25038 (/IMP) P25038 (/IMP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 F7FDM3 (/TAS) P46199 (/TAS) Q68FQ5 (/TAS)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
3 P25038 (/HDA) P25038 (/HDA) P25038 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8MS23 (/ISS) Q9VAV2 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P46199 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q91YJ5 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P46198 (/IC)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P46199 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q91YJ5 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 O59683 (/IC)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P46198 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8I3U2 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q9SHI1 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q9SHI1 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 Q9SHI1 (/IDA)