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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Transitional endoplasmic reticulum ATPase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Vesicle-fusing ATPase. [EC: 3.6.4.6]
ATP + H(2)O = ADP + phosphate.
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
 644 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03 A0A0D9RD03
(634 more...)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10]
ATP + H(2)O = ADP + phosphate.
  • This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
  • They comprise a number of heat-shock-cognate proteins.
  • They are also active in clathrin uncoating and in the oligomerization of actin.
 28 A0A0L8VLC2 A0A0L8VLC2 A0A0L8VLC2 A0A0L8VLC2 A0A0L8VLC2 C8ZE06 C8ZE06 C8ZE06 C8ZE06 C8ZE06
(18 more...)