The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Two-component system response regulator ArcA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
215 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(205 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
195 P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI)
(185 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
195 P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI)
(185 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
191 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(181 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
191 P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS)
(181 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
191 P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI)
(181 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
191 P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI)
(181 more)
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
24 Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS)
(14 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
17 Q5E2Y1 (/IDA) Q5E2Y1 (/IDA) Q5E2Y1 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA)
(7 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
4 Q5E2Y1 (/IDA) Q5E2Y1 (/IDA) Q5E2Y1 (/IDA) Q8EHJ3 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q8EHJ3 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
1 Q8EHJ3 (/IDA)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
1 Q8EHJ3 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
1 Q8EHJ3 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
215 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(205 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
191 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(181 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
191 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(181 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
191 P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS)
(181 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
191 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(181 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
191 P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS) P0A9Q1 (/ISS)
(181 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
24 Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS)
(14 more)
Anaerobic respiration GO:0009061
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.
16 Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS) Q9KPJ9 (/ISS)
(6 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
4 Q5E2Y1 (/EXP) Q5E2Y1 (/EXP) Q5E2Y1 (/EXP) Q8EHJ3 (/EXP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P44918 (/IMP) P44918 (/IMP) P44918 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 Q5E2Y1 (/IEP) Q5E2Y1 (/IEP) Q5E2Y1 (/IEP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8EHJ3 (/EXP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
195 P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI) P0A9Q1 (/IPI)
(185 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
191 P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA) P0A9Q1 (/IDA)
(181 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
17 Q5E2Y1 (/IDA) Q5E2Y1 (/IDA) Q5E2Y1 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA) Q8EAB9 (/IDA)
(7 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 Q8EHJ3 (/IMP)
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