The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 131: Piwi-like RNA-mediated gene silencing 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q8UVX0 (/IPI) Q96J94 (/IPI) Q96J94 (/IPI) Q9JMB7 (/IPI) Q9JMB7 (/IPI)
PiRNA binding GO:0034584
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
5 Q8UVX0 (/IDA) Q96J94 (/IDA) Q96J94 (/IDA) Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
4 A6N7Y9 (/ISS) Q8UVX0 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
3 A6N7Y9 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2 Q9JMB7 (/IMP) Q9JMB7 (/IMP)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q9JMB7 (/IPI) Q9JMB7 (/IPI)
PiRNA binding GO:0034584
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
2 Q9JMB7 (/ISO) Q9JMB7 (/ISO)
MRNA cap binding complex binding GO:0140262
Interacting selectively and non-covalently with a mRNA cap binding complex.
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Polysome binding GO:1905538
Interacting selectively and non-covalently with a polysome.
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
PiRNA binding GO:0034584
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
1 A6N7Y9 (/ISS)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
5 A6N7Y9 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS) Q9JMB7 (/ISS) Q9JMB7 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 A6N7Y9 (/ISS) Q8UVX0 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
4 Q96J94 (/IMP) Q96J94 (/IMP) Q9JMB7 (/IMP) Q9JMB7 (/IMP)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
4 A6N7Y9 (/ISS) Q8UVX0 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
Negative regulation of transposition GO:0010529
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
4 A6N7Y9 (/ISS) Q8UVX0 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
Spermatogenesis, exchange of chromosomal proteins GO:0035093
The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin.
4 A6N7Y9 (/ISS) Q8UVX0 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
3 Q8UVX0 (/IMP) Q9JMB7 (/IMP) Q9JMB7 (/IMP)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
3 A6N7Y9 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 A6N7Y9 (/ISS) Q8UVX0 (/ISS)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 Q9JMB7 (/NAS) Q9JMB7 (/NAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q9JMB7 (/IMP) Q9JMB7 (/IMP)
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
2 Q9JMB7 (/ISO) Q9JMB7 (/ISO)
Negative regulation of transposition GO:0010529
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
2 Q9JMB7 (/IMP) Q9JMB7 (/IMP)
Spermatogenesis, exchange of chromosomal proteins GO:0035093
The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin.
2 Q9JMB7 (/IMP) Q9JMB7 (/IMP)
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
1 Q8UVX0 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q8UVX0 (/IDA)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q8UVX0 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 Q8UVX0 (/IDA)
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
1 Q8UVX0 (/IMP)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
1 Q8UVX0 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
5 A6N7Y9 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS) Q9JMB7 (/ISS) Q9JMB7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q7Z3Z3 (/IDA) Q8UVX0 (/IDA) Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q7Z3Z3 (/IDA) Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A6N7Y9 (/ISS) Q96J94 (/ISS) Q96J94 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9JMB7 (/TAS) Q9JMB7 (/TAS)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
2 Q96J94 (/ISS) Q96J94 (/ISS)
Dense body GO:0097433
An electron dense body which may contain granules.
2 Q9JMB7 (/IDA) Q9JMB7 (/IDA)
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
1 Q8UVX0 (/IDA)
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