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CATH Superfamily 3.40.50.2000

Glycogen Phosphorylase B;

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycogen Phosphorylase B;
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 391: 2-deoxystreptamine N-acetyl-D-glucosaminyltransfer...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase. [EC: 2.4.1.283]
UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine = UDP + 2'-N- acetylparomamine.
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
  • Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose (cf. EC 2.4.1.284), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-alpha-D- glucosamine.
 10 A0A1Y2NRU3 A0A1Y2NRU3 A0A1Y2NRU3 A0A286MPS3 A0A286MPS3 A0A286MPS3 Q53U18 Q53U18 Q53U18 Q65CC1
2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase. [EC: 2.4.1.301]
(1) UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine = UDP + kanamycin A. (2) UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B. (3) UDP-alpha-D-kanosamine + paromamine = UDP + kanamycin C. (4) UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine = UDP + kanamycin X.
  • Involved in the biosynthetic pathway of kanamycins.
  • The enzyme characterized from the bacterium Streptomyces kanamyceticus can also accept UDP-alpha-D-glucose with lower efficiency.
 1 Q65CC7
2-deoxystreptamine glucosyltransferase. [EC: 2.4.1.284]
UDP-alpha-D-glucose + 2-deoxystreptamine = UDP + 2'-deamino- 2'-hydroxyparomamine.
  • Involved in the biosynthesis of kanamycin B and kanamycin C.
  • Also catalyzes EC 2.4.1.283, but activity is only one fifth of that with UDP-alpha-D-glucose.
 1 Q65CC1
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