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CATH Superfamily 3.40.50.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Propionyl-CoA carboxylase subunit alpha

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Biotin carboxylase. [EC: 6.3.4.14]
ATP + [biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]- carboxybiotin-N(6)-L-lysine.
  • This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15.
  • In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria).
  • Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyzes the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2).
 14 A0A0H3MUF1 A0A0H3MUF1 A0A0H3MUF1 A0A178U9M2 A0A178U9M2 A0A197SFS5 A0A197SFS5 A0A197SFS5 I3R7G3 O04983
(4 more...)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]
ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl- CoA.
  • Also carboxylates butanoyl-CoA and catalyzes transcarboxylation.
 9 I3R7G3 P05165 P14882 Q19842 Q3UGC8 Q3UGC8 Q612F5 Q91ZA3 Q91ZA3
Acetyl-CoA carboxylase. [EC: 6.4.1.2]
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
  • This enzyme is a multi-domain polypeptide that catalyzes three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyzes the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA.
  • In some organisms these activities are catalyzed by separate enzymes (see EC 6.3.4.14 and EC 2.1.3.15).
  • The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
 4 A0A178U9M2 A0A178U9M2 O04983 O04983
Methylcrotonoyl-CoA carboxylase. [EC: 6.4.1.4]
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA.
    		 1 Q54KE6
    Pyruvate carboxylase. [EC: 6.4.1.1]
    ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.
    • The animal enzyme requires acetyl-CoA.
    		 1 P52873
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