The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 67: Bifunctional epoxide hydrolase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
4 F1R264 (/IDA) P34913 (/IDA) P80299 (/IDA) Q5PRC6 (/IDA)
Lipid phosphatase activity GO:0042577
Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
4 P34914 (/ISS) P80299 (/ISS) Q6Q2C2 (/ISS) Q6Q2C2 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 P34914 (/ISS) Q6Q2C2 (/ISS) Q6Q2C2 (/ISS)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
2 P34913 (/IDA) P80299 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P34913 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P80299 (/IMP)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P34914 (/ISO)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
1 P34914 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P34914 (/ISO)
Toxic substance binding GO:0015643
Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems.
1 P34913 (/IDA)
Toxic substance binding GO:0015643
Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems.
1 P34914 (/ISO)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 P34914 (/ISO)
Lipid phosphatase activity GO:0042577
Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
1 P34913 (/IDA)
Lipid phosphatase activity GO:0042577
Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
1 P34914 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P34913 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P34914 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P34913 (/NAS)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipid dephosphorylation GO:0046839
The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
4 P34914 (/ISS) P80299 (/ISS) Q6Q2C2 (/ISS) Q6Q2C2 (/ISS)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
2 F1R264 (/IMP) Q5PRC6 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P34913 (/IDA) P34914 (/IDA)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
2 P34913 (/IDA) P34914 (/IDA)
Venous blood vessel development GO:0060841
The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.
2 F1R264 (/IMP) Q5PRC6 (/IMP)
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
2 P34913 (/IMP) P34914 (/IMP)
Prostaglandin production involved in inflammatory response GO:0002539
The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
1 P80299 (/IMP)
Prostaglandin production involved in inflammatory response GO:0002539
The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
1 P34914 (/ISO)
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
1 P34913 (/TAS)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
1 P34913 (/NAS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 P34913 (/NAS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P80299 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P34914 (/ISO)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P34913 (/NAS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 P34913 (/NAS)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 P34913 (/NAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P34914 (/ISO)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 P34913 (/IDA)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 P34914 (/ISO)
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
1 P34913 (/NAS)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
1 P80299 (/IMP)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
1 P34914 (/ISO)
Epoxygenase P450 pathway GO:0019373
The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.
1 P34913 (/TAS)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 P34914 (/ISO)
Long-chain fatty acid biosynthetic process GO:0042759
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.
1 P34913 (/TAS)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
1 P80299 (/IMP)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
1 P34914 (/ISO)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 P80299 (/IMP)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 P34914 (/ISO)
Stilbene catabolic process GO:0046272
The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA.
1 P34913 (/IDA)
Stilbene catabolic process GO:0046272
The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA.
1 P34914 (/ISO)
Phospholipid dephosphorylation GO:0046839
The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
1 P34913 (/IDA)
Phospholipid dephosphorylation GO:0046839
The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
1 P34914 (/ISO)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
1 P34913 (/NAS)
Regulation of cholesterol metabolic process GO:0090181
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 P34914 (/ISO)
Epoxide metabolic process GO:0097176
The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers.
1 P34913 (/IDA)
Epoxide metabolic process GO:0097176
The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers.
1 P34914 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 P34913 (/NAS)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 E5RFH6 (/IDA) E5RFU2 (/IDA) P34913 (/IDA) P80299 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 P34913 (/IDA) P80299 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P34913 (/TAS) P80299 (/TAS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 P34914 (/ISO)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 P80299 (/TAS)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
1 P34913 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P34914 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P34913 (/NAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P34913 (/HDA)
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