The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 183: Phosphatidylcholine-sterol acyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylcholine-sterol O-acyltransferase activity GO:0004607
Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
6 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P16301 (/IDA) P18424 (/IDA)
Phosphatidylcholine-sterol O-acyltransferase activity GO:0004607
Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
6 O35573 (/ISS) O35724 (/ISS) O35840 (/ISS) P53760 (/ISS) P53761 (/ISS) Q08758 (/ISS)
Phosphatidylcholine-sterol O-acyltransferase activity GO:0004607
Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
4 P04180 (/NAS) P04180 (/NAS) P04180 (/NAS) P04180 (/NAS)
Phosphatidylcholine-sterol O-acyltransferase activity GO:0004607
Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
4 P04180 (/TAS) P04180 (/TAS) P04180 (/TAS) P04180 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P04180 (/IPI) P04180 (/IPI) P04180 (/IPI) P04180 (/IPI)
Apolipoprotein A-I binding GO:0034186
Interacting selectively and non-covalently with apolipoprotein A-I.
4 P04180 (/IPI) P04180 (/IPI) P04180 (/IPI) P04180 (/IPI)
Phosphatidylcholine-sterol O-acyltransferase activity GO:0004607
Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.
1 P16301 (/ISO)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
1 P18424 (/IDA)
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
1 P16301 (/ISO)
Apolipoprotein A-I binding GO:0034186
Interacting selectively and non-covalently with apolipoprotein A-I.
1 P16301 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cholesterol esterification GO:0034435
A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.
8 O35573 (/ISS) O35724 (/ISS) O35840 (/ISS) P16301 (/ISS) P18424 (/ISS) P53760 (/ISS) P53761 (/ISS) Q08758 (/ISS)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
8 O35573 (/ISS) O35724 (/ISS) O35840 (/ISS) P16301 (/ISS) P18424 (/ISS) P53760 (/ISS) P53761 (/ISS) Q08758 (/ISS)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
6 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P16301 (/IDA) P18424 (/IDA)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
6 O35573 (/ISS) O35724 (/ISS) O35840 (/ISS) P53760 (/ISS) P53761 (/ISS) Q08758 (/ISS)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Very-low-density lipoprotein particle remodeling GO:0034372
The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
High-density lipoprotein particle remodeling GO:0034375
The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
High-density lipoprotein particle remodeling GO:0034375
The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.
4 P04180 (/TAS) P04180 (/TAS) P04180 (/TAS) P04180 (/TAS)
Cholesterol esterification GO:0034435
A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Reverse cholesterol transport GO:0043691
The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P16301 (/ISO)
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
1 P16301 (/ISO)
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
1 P16301 (/ISO)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P16301 (/ISO)
Very-low-density lipoprotein particle remodeling GO:0034372
The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.
1 P16301 (/ISO)
High-density lipoprotein particle remodeling GO:0034375
The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.
1 P16301 (/ISO)
Cholesterol esterification GO:0034435
A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.
1 P16301 (/ISO)
Lipoprotein metabolic process GO:0042157
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 P18424 (/IDA)
Lipoprotein metabolic process GO:0042157
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 P16301 (/ISO)
Lipoprotein biosynthetic process GO:0042158
The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 P16301 (/IDA)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 P16301 (/ISO)
Reverse cholesterol transport GO:0043691
The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.
1 P16301 (/ISO)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
1 P16301 (/ISO)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 P18424 (/IDA)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 P16301 (/ISO)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P18424 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P16301 (/ISO)
Regulation of high-density lipoprotein particle assembly GO:0090107
Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.
1 P16301 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P16301 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 P04180 (/TAS) P04180 (/TAS) P04180 (/TAS) P04180 (/TAS)
High-density lipoprotein particle GO:0034364
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
4 P04180 (/IDA) P04180 (/IDA) P04180 (/IDA) P04180 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P04180 (/HDA) P04180 (/HDA) P04180 (/HDA) P04180 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P16301 (/ISO)
High-density lipoprotein particle GO:0034364
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
1 P16301 (/ISO)
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