The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoside phosphorylase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Probable 6-oxopurine nucleoside phosphorylase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
S-methyl-5'-thioadenosine phosphorylase. [EC: 2.4.2.28]
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha- D-ribose 1-phosphate.
  • Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups.
11 A0A0E3JSQ3 A0A0E3JSQ3 A0A2A6N5Y0 A0A2A6N5Y0 A9A3N5 Q5JEQ6 Q89VT5 Q89VT5 Q8ZTB2 Q97W94
(1 more...)
Purine-nucleoside phosphorylase. [EC: 2.4.2.1]
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
  • Specificity not completely determined.
  • Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.
4 B1L719 B8E181 O66839 Q5JJB8
S-methyl-5'-thioinosine phosphorylase. [EC: 2.4.2.44]
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio- alpha-D-ribose 1-phosphate.
  • No activity with S-methyl-5'-thioadenosine.
  • The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31) and phosphorolysis to hypoxanthine.
1 Q60367
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