The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: rRNA adenine N(6)-methyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179
Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
13 P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) P41819 (/ISS) Q2KHT8 (/ISS)
(3 more)
RRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179
Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
11 O22268 (/IMP) O22268 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP)
(1 more)
RRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179
Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
9 Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP) Q9UNQ2 (/EXP)
RRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179
Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
9 P41819 (/NAS) P41819 (/NAS) P41819 (/NAS) P41819 (/NAS) P41819 (/NAS) P41819 (/NAS) P41819 (/NAS) P41819 (/NAS) P41819 (/NAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA) Q9UNQ2 (/HDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
2 Q5B817 (/RCA) Q5B817 (/RCA)
RRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179
Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.
1 Q9D0D4 (/ISO)
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity GO:0052909
Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.
1 Q9USU2 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA modification GO:0000154
The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
9 P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP)
Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462
Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
9 P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP) P41819 (/IMP)
RRNA methylation GO:0031167
The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
9 Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP)
RRNA methylation GO:0031167
The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
9 Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS)
Positive regulation of rRNA processing GO:2000234
Any process that activates or increases the frequency, rate or extent of rRNA processing.
9 Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP) Q9UNQ2 (/IMP)
RRNA methylation GO:0031167
The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
4 Q2KHT8 (/ISS) Q2KHT8 (/ISS) Q95KJ0 (/ISS) Q9D0D4 (/ISS)
Positive regulation of rRNA processing GO:2000234
Any process that activates or increases the frequency, rate or extent of rRNA processing.
4 Q2KHT8 (/ISS) Q2KHT8 (/ISS) Q95KJ0 (/ISS) Q9D0D4 (/ISS)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
2 O22268 (/IMP) O22268 (/IMP)
Histidine metabolic process GO:0006547
The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
2 Q5B817 (/RCA) Q5B817 (/RCA)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
2 O22268 (/IMP) O22268 (/IMP)
Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462
Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
1 Q9USU2 (/ISO)
RRNA methylation GO:0031167
The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
1 Q9D0D4 (/ISO)
Positive regulation of rRNA processing GO:2000234
Any process that activates or increases the frequency, rate or extent of rRNA processing.
1 Q9D0D4 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) O22268 (/IDA) O22268 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA)
(5 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
15 A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) O22268 (/IDA) O22268 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) A0A0C4DGB1 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA) Q9UNQ2 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS) Q9UNQ2 (/TAS)
90S preribosome GO:0030686
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
9 P41819 (/HDA) P41819 (/HDA) P41819 (/HDA) P41819 (/HDA) P41819 (/HDA) P41819 (/HDA) P41819 (/HDA) P41819 (/HDA) P41819 (/HDA)
Preribosome, small subunit precursor GO:0030688
A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
9 P41819 (/IDA) P41819 (/IDA) P41819 (/IDA) P41819 (/IDA) P41819 (/IDA) P41819 (/IDA) P41819 (/IDA) P41819 (/IDA) P41819 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
4 Q2KHT8 (/ISS) Q2KHT8 (/ISS) Q95KJ0 (/ISS) Q9D0D4 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9USU2 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9D0D4 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9USU2 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9D0D4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9D0D4 (/ISO)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 Q9USU2 (/HDA)
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