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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 473: RNA-directed RNA polymerase L

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GDP polyribonucleotidyltransferase. [EC: 2.7.7.88]
5'-triphospho-mRNA + GDP = diphosphate + guanosine 5'-triphospho-mRNA.
  • The enzyme from rhabdoviruses transfers 5'-monophosphorylated (p-)mRNA from 5'-triphosphorylated (ppp-)mRNA to GDP to form 5'-capped mRNA (GpppmRNA) in a viral mRNA-start sequence-dependent manner.
  • The (p-)mRNA transfer reaction proceeds through a covalent enzyme- pmRNA intermediate.
 6 P03523 Q8B0H0 Q8B0H5 Q8B0I0 Q91DR9 Q98776
RNA-directed RNA polymerase. [EC: 2.7.7.48]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • See also EC 2.7.7.6.
 6 P03523 Q8B0H0 Q8B0H5 Q8B0I0 Q91DR9 Q98776
Methyltransferase cap2. [EC: 2.1.1.296]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl- L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl- purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA].
  • The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the nucleoside at the second transcribed position of mRNAs and snRNAs.
  • This methylation is known as cap2.
  • The human enzyme can also methylate mRNA molecules where the upstream purine ribonucleotide is not methylated (see EC 2.1.1.57), but with lower efficiency.
 6 P03523 Q8B0H0 Q8B0H5 Q8B0I0 Q91DR9 Q98776
MRNA (guanine-N(7)-)-methyltransferase. [EC: 2.1.1.56]
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
  • Adds an N(7)-methylguanine cap to mRNA.
  • The nucleoside next to the terminal guanosine may be either guanosine or adenosine.
 6 P03523 Q8B0H0 Q8B0H5 Q8B0I0 Q91DR9 Q98776
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