View in Gene3D

CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 461: Sarcosine/dimethylglycine N-methyltransferase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sarcosine/dimethylglycine N-methyltransferase. [EC: 2.1.1.157]
2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • The first enzyme, EC 2.1.1.156, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
  • Both of these enzymes can catalyze the formation of N,N-dimethylglycine from sarcosine.
  • The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
 9 A0A0X8XB40 A0A0X8XB40 K9YGK5 K9YGK5 Q83WC3 Q83WC3 Q9KJ20 Q9KJ21 Q9KJ21
Dimethylglycine N-methyltransferase. [EC: 2.1.1.161]
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine.
  • This enzyme, from the marine cyanobacterium Synechococcus sp. strain WH8102, differs from EC 2.1.1.157 in that it cannot use sarcosine as an alternative substrate.
  • Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.
 1 Q7U4Z9
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase. [EC: 2.1.1.99]
S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline.
  • Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle Catharanthus roseus.
 1 W5U2K2
Glycine/sarcosine N-methyltransferase. [EC: 2.1.1.156]
2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
  • Differs from EC 2.1.1.20, as it can further methylate the product of the first reaction.
  • Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction.
 1 Q9KJ20
CATH-Gene3D is a Global Biodata Core Resource Learn more...