The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Vaccinia Virus protein VP39
".
FunFam 362: Histidine N-alpha-methyltransferase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein methyltransferase activity GO:0008276
Catalysis of the transfer of a methyl group (CH3-) to a protein.
|
18 |
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN47 (/ISS)
(8 more) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | O94632 (/ISS) |
|
Protein methyltransferase activity GO:0008276
Catalysis of the transfer of a methyl group (CH3-) to a protein.
|
1 | A0R5M8 (/IDA) |
|
Hercynylselenocysteine synthase GO:0044876
Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine.
|
1 | O94632 (/IMP) |
|
Histidine N-methyltransferase activity GO:0052706
Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine.
|
1 | O94632 (/IMP) |
|
Hercynylcysteine sulfoxide synthase GO:0061686
Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine + O2 <=> hercynylcysteine sulfoxide + H2O.
|
1 | O94632 (/IMP) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine GO:0052704
The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine.
|
18 |
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN47 (/ISS)
(8 more) |
|
N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine GO:0052707
The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine).
|
18 |
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN46 (/ISS)
P9WN47 (/ISS)
(8 more) |
|
Ergothioneine biosynthetic process GO:0052699
The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties.
|
1 | O94632 (/IMP) |
|
Ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine GO:0052704
The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine.
|
1 | A0R5M8 (/IDA) |
|
N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine GO:0052707
The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine).
|
1 | A0R5M8 (/IDA) |
|
N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine GO:0052707
The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine).
|
1 | O94632 (/IMP) |
|
Hercynylcysteine sulfoxide biosynthetic process GO:1903253
The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide.
|
1 | O94632 (/IMP) |
|
Hercynylselenocysteine biosynthetic process GO:1903255
The chemical reactions and pathways resulting in the formation of hercynylselenocysteine.
|
1 | O94632 (/IMP) |
|
Selenoneine biosynthetic process GO:1903257
The chemical reactions and pathways resulting in the formation of selenoneine.
|
1 | O94632 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) P9WN47 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94632 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O94632 (/HDA) |
