The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Adenosylhomocysteinase-like
".
FunFam 4: Adenosylhomocysteinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
18 |
P23526 (/IPI)
P23526 (/IPI)
P23526 (/IPI)
P23526 (/IPI)
P23526 (/IPI)
P39954 (/IPI)
P39954 (/IPI)
P39954 (/IPI)
P39954 (/IPI)
P39954 (/IPI)
(8 more) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
10 | P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
10 | P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
6 | P10819 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
4 | P10760 (/IDA) P50247 (/IDA) P50247 (/IDA) P50247 (/IDA) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
4 | O13639 (/ISO) P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
4 | P10819 (/ISS) P27604 (/ISS) Q27580 (/ISS) Q27580 (/ISS) |
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
|
3 | P50247 (/IDA) P50247 (/IDA) P50247 (/IDA) |
Adenyl nucleotide binding GO:0030554
Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
3 | P50247 (/IPI) P50247 (/IPI) P50247 (/IPI) |
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Adenosylhomocysteinase activity GO:0004013
Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
|
2 | Q5BDW7 (/RCA) Q5BDW7 (/RCA) |
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
|
1 | P10819 (/TAS) |
Adenyl nucleotide binding GO:0030554
Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.
|
1 | P10760 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P10760 (/IDA) |
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
1 | P10760 (/IDA) |
Adenosylselenohomocysteinase activity GO:0098604
Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine.
|
1 | P10760 (/TAS) |
There are 21 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
S-adenosylhomocysteine catabolic process GO:0019510
The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.
|
12 |
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
P39954 (/IMP)
(2 more) |
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
|
10 | P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) |
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
|
10 | P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) P39954 (/IMP) |
S-adenosylhomocysteine catabolic process GO:0019510
The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.
|
10 | P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) P39954 (/ISA) |
Sulfur amino acid metabolic process GO:0000096
The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
|
5 | P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) |
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
|
5 | P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) |
S-adenosylhomocysteine catabolic process GO:0019510
The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.
|
4 | P10760 (/IDA) P50247 (/IDA) P50247 (/IDA) P50247 (/IDA) |
Chronic inflammatory response to antigenic stimulus GO:0002439
A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
S-adenosylhomocysteine catabolic process GO:0019510
The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Circadian sleep/wake cycle GO:0042745
The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
2 | Q5BDW7 (/RCA) Q5BDW7 (/RCA) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P10760 (/IEP) |
Chronic inflammatory response to antigenic stimulus GO:0002439
A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.
|
1 | P10760 (/IMP) |
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
|
1 | O13639 (/ISO) |
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
|
1 | P10819 (/IMP) |
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
1 | P10760 (/IDA) |
Selenocysteine metabolic process GO:0016259
The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.
|
1 | O13639 (/ISO) |
S-adenosylhomocysteine catabolic process GO:0019510
The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.
|
1 | P27604 (/ISS) |
S-adenosylmethionine cycle GO:0033353
A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine.
|
1 | Q803T5 (/IMP) |
Circadian sleep/wake cycle GO:0042745
The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
|
1 | P10760 (/IDA) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
10 | P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) P39954 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
9 | P10760 (/IDA) P23526 (/IDA) P23526 (/IDA) P23526 (/IDA) P23526 (/IDA) P23526 (/IDA) P50247 (/IDA) P50247 (/IDA) P50247 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P10760 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) P23526 (/TAS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
5 | P23526 (/HDA) P23526 (/HDA) P23526 (/HDA) P23526 (/HDA) P23526 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
3 | P50247 (/ISO) P50247 (/ISO) P50247 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P10760 (/IDA) P10819 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P27604 (/ISS) Q3MHL4 (/ISS) |
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
|
2 | P83783 (/IDA) P83783 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P10819 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O13639 (/HDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | P10819 (/IDA) |
Actin rod GO:0031002
A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions.
|
1 | P10819 (/IDA) |
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
|
1 | P10819 (/HDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | P10760 (/IDA) |
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
|
1 | P10819 (/HDA) |