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CATH Superfamily 3.40.50.1400

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Sirohydrochlorin cobaltochelatase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sirohydrochlorin cobaltochelatase. [EC: 4.99.1.3]
Cobalt-sirohydrochlorin + 2 H(+) = sirohydrochlorin + Co(2+).
  • This enzyme is a type II chelatase, being either a monomer (CbiX) or a homodimer (CibK) and being ATP-independent.
  • CbiK from Salmonella enterica uses precorrin-2 as the substrate to yield cobalt-precorrin-2.
  • The enzyme contains two histidines at the active site that are thought to be involved in the deprotonation of the tetrapyrrole substrate as well as in metal binding.
  • CbiX from Bacillus megaterium inserts cobalt at the level of sirohydrochlorin (factor-II) rather than precorrin-2.
 2112 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2 A0A0D6FJP2
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