The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Long-chain fatty acid transport protein 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
5 Q60714 (/IDA) Q60714 (/IDA) Q6P1M0 (/IDA) Q6P1M0 (/IDA) Q91VE0 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P97849 (/IPI) Q60714 (/IPI) Q60714 (/IPI) Q6PCB7 (/IPI)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 P97849 (/ISS) Q3ZKN0 (/ISS) Q6PCB7 (/ISS)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q60714 (/TAS) Q60714 (/TAS) Q91VE0 (/TAS)
Very long-chain fatty acid-CoA ligase activity GO:0031957
Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.
3 Q60714 (/IDA) Q60714 (/IDA) Q91VE0 (/IDA)
Very long-chain fatty acid-CoA ligase activity GO:0031957
Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.
3 Q60714 (/IMP) Q60714 (/IMP) Q91VE0 (/IMP)
Fatty acid transmembrane transporter activity GO:0015245
Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
2 Q60714 (/IDA) Q60714 (/IDA)
Fatty acid transmembrane transporter activity GO:0015245
Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
2 Q60714 (/IGI) Q60714 (/IGI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q60714 (/IDA) Q60714 (/IDA)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q91VE0 (/ISO)
Fatty acid transmembrane transporter activity GO:0015245
Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 P97849 (/NAS)

There are 43 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Long-chain fatty acid import into cell GO:0044539
The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
4 Q60714 (/IDA) Q60714 (/IDA) Q6P1M0 (/IDA) Q6P1M0 (/IDA)
Medium-chain fatty acid transport GO:0001579
The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.
3 Q60714 (/IGI) Q60714 (/IGI) Q91VE0 (/IGI)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q6P1M0 (/IDA) Q6P1M0 (/IDA) Q91VE0 (/IDA)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q60714 (/TAS) Q60714 (/TAS) Q91VE0 (/TAS)
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
3 P97849 (/ISS) Q3ZKN0 (/ISS) Q6PCB7 (/ISS)
Long-chain fatty acid transport GO:0015909
The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q60714 (/IMP) Q60714 (/IMP) Q91VE0 (/IMP)
Long-chain fatty acid transport GO:0015909
The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q6P1M0 (/TAS) Q6P1M0 (/TAS) Q6PCB7 (/TAS)
Long-chain fatty acid import into cell GO:0044539
The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q60714 (/ISO) Q60714 (/ISO) Q91VE0 (/ISO)
Phosphatidylethanolamine biosynthetic process GO:0006646
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
2 Q60714 (/ISO) Q60714 (/ISO)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
2 Q60714 (/ISO) Q60714 (/ISO)
Phosphatidylglycerol biosynthetic process GO:0006655
The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
2 Q60714 (/ISO) Q60714 (/ISO)
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
2 Q60714 (/ISO) Q60714 (/ISO)
Phosphatidylserine biosynthetic process GO:0006659
The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
2 Q60714 (/ISO) Q60714 (/ISO)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 Q60714 (/ISO) Q60714 (/ISO)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
2 Q60714 (/IMP) Q60714 (/IMP)
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
2 Q60714 (/IDA) Q60714 (/IDA)
Fatty acid transport GO:0015908
The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
2 Q60714 (/IDA) Q60714 (/IDA)
Fatty acid transport GO:0015908
The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
2 Q60714 (/IMP) Q60714 (/IMP)
Positive regulation of heat generation GO:0031652
Any process that activates or increases the rate or extent of heat generation.
2 Q60714 (/IMP) Q60714 (/IMP)
Cardiolipin biosynthetic process GO:0032049
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
2 Q60714 (/ISO) Q60714 (/ISO)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 Q60714 (/IMP) Q60714 (/IMP)
Adiponectin-activated signaling pathway GO:0033211
A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q60714 (/IMP) Q60714 (/IMP)
Long-chain fatty acid import into cell GO:0044539
The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
2 P97849 (/ISS) Q3ZKN0 (/ISS)
Negative regulation of phospholipid biosynthetic process GO:0071072
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids.
2 Q60714 (/ISO) Q60714 (/ISO)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
2 Q60714 (/IMP) Q60714 (/IMP)
Very long-chain fatty acid metabolic process GO:0000038
The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
1 Q91VE0 (/IDA)
Very long-chain fatty acid metabolic process GO:0000038
The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.
1 Q91VE0 (/IMP)
Medium-chain fatty acid transport GO:0001579
The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.
1 Q91VE0 (/IDA)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q91VE0 (/ISO)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 Q91VE0 (/IMP)
Phosphatidylethanolamine biosynthetic process GO:0006646
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
1 Q6PCB7 (/IMP)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q6PCB7 (/IMP)
Phosphatidylglycerol biosynthetic process GO:0006655
The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
1 Q6PCB7 (/IMP)
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
1 Q6PCB7 (/IMP)
Phosphatidylserine biosynthetic process GO:0006659
The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q6PCB7 (/IMP)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 Q6PCB7 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 G3V7V3 (/IEP)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 Q6PCB7 (/TAS)
Cardiolipin biosynthetic process GO:0032049
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
1 Q6PCB7 (/IMP)
Very long-chain fatty acid catabolic process GO:0042760
The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.
1 Q91VE0 (/IDA)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
1 Q91VE0 (/IMP)
Long-chain fatty acid import into cell GO:0044539
The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q6PCB7 (/IMP)
Negative regulation of phospholipid biosynthetic process GO:0071072
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids.
1 Q6PCB7 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q60714 (/TAS) Q60714 (/TAS) Q6P1M0 (/TAS) Q6P1M0 (/TAS) Q6PCB7 (/TAS) Q91VE0 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P97849 (/IDA) Q60714 (/IDA) Q60714 (/IDA) Q6PCB7 (/IDA) Q91VE0 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 Q60714 (/IDA) Q60714 (/IDA) Q91VE0 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q6P1M0 (/HDA) Q6P1M0 (/HDA) Q6PCB7 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P97849 (/IDA) Q6PCB7 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q60714 (/ISO) Q60714 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q6P1M0 (/IDA) Q6P1M0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q60714 (/ISO) Q60714 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q60714 (/ISO) Q60714 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q60714 (/IDA) Q60714 (/IDA)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 Q60714 (/ISO) Q60714 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q60714 (/TAS) Q60714 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q60714 (/ISO) Q60714 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q91VE0 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PCB7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q3ZKN0 (/ISS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 P97849 (/IDA)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 Q91VE0 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q91VE0 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P97849 (/IDA)
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