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CATH Superfamily 3.40.50.12780

ANL, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 59: Coronamic acid synthetase CmaA

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase. [EC: 6.2.1.46]
ATP + L-allo-isoleucine + holo-[CmaA peptidyl-carrier protein] = AMP + diphosphate + L-allo-isoleucyl-S-[CmaA peptidyl-carrier protein].
  • This two-domain protein from the bacterium Pseudomonas syringae contains an adenylation domain (A domain) and a thiolation domain (T domain).
  • It catalyzes the adenylation of L-allo-isoleucine and its attachment to the T domain.
  • The enzyme is involved in the biosynthesis of the toxin coronatine, which mimics the plant hormone jasmonic acid isoleucine.
  • Coronatine promotes opening of the plant stomata allowing bacterial invasion, which is followed by bacterial growth in the apoplast, systemic susceptibility, and disease.
 16 A0A0P9H3J5 A0A0P9H3J5 A0A0P9H3J5 A0A0P9H3J5 A0A3M3HAR1 A0A3M3HAR1 A0A3M3HAR1 A0A3M3HAR1 A0A3M4J0P3 A0A3M4J0P3
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