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CATH Superfamily 3.40.50.12780

ANL, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Acyl-CoA synthetase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Long-chain-fatty-acid--CoA ligase. [EC: 6.2.1.3]
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
  • Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
  • The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).
 57 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A120IQF0 A0A120IQF0 A0A120IQF0
(47 more...)
3-oxocholest-4-en-26-oate--CoA ligase. [EC: 6.2.1.42]
ATP + (25S)-3-oxocholest-4-en-26-oate + CoA = AMP + diphosphate + (25S)- 3-oxocholest-4-en-26-oyl-CoA.
  • The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyzes a step in the degradation of cholesterol.
  • It is responsible for the activation of the C8 side chain.
  • 3-beta-hydroxycholest-5-en-26-oate can also be used as substrate.
 57 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A0H3M9B4 A0A120IQF0 A0A120IQF0 A0A120IQF0
(47 more...)
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