The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphoglycerate mutase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Putative fructose-2,6-bisphosphatase TIGAR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bisphosphoglycerate 2-phosphatase activity GO:0004083
Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Bisphosphoglycerate 2-phosphatase activity GO:0004083
Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Bisphosphoglycerate 2-phosphatase activity GO:0004083
Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
1 Q9NQ88 (/IDA)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
1 Q9NQ88 (/EXP)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
1 Q9NQ88 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9NQ88 (/IPI)

There are 43 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Fructose 1,6-bisphosphate metabolic process GO:0030388
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Regulation of pentose-phosphate shunt GO:0043456
Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Regulation of response to DNA damage checkpoint signaling GO:1902153
Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Positive regulation of hexokinase activity GO:1903301
Any process that activates or increases the frequency, rate or extent of hexokinase activity.
3 Q1JQA7 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 Q8BZA9 (/IDA) Q8BZA9 (/IDA)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 Q1JQA7 (/ISS) Q9NQ88 (/ISS)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Fructose 1,6-bisphosphate metabolic process GO:0030388
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Negative regulation of kinase activity GO:0033673
Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 Q8BZA9 (/IC) Q8BZA9 (/IC)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Regulation of pentose-phosphate shunt GO:0043456
Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
2 Q8BZA9 (/IDA) Q8BZA9 (/IDA)
Intestinal epithelial cell development GO:0060576
The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Cellular response to cobalt ion GO:0071279
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
2 Q8BZA9 (/IDA) Q8BZA9 (/IDA)
Negative regulation of mitophagy GO:1901525
Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Regulation of response to DNA damage checkpoint signaling GO:1902153
Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Positive regulation of hexokinase activity GO:1903301
Any process that activates or increases the frequency, rate or extent of hexokinase activity.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Negative regulation of glucose catabolic process to lactate via pyruvate GO:1904024
Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Negative regulation of reactive oxygen species metabolic process GO:2000378
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
2 Q8BZA9 (/IMP) Q8BZA9 (/IMP)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
1 Q9NQ88 (/IDA)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q9NQ88 (/IDA)
Fructose 1,6-bisphosphate metabolic process GO:0030388
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
1 Q9NQ88 (/IDA)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
1 Q9NQ88 (/IDA)
Regulation of pentose-phosphate shunt GO:0043456
Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.
1 Q9NQ88 (/IMP)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
1 Q9NQ88 (/IMP)
Cellular response to cobalt ion GO:0071279
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
1 Q9NQ88 (/IDA)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9NQ88 (/IDA)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q1JQA7 (/ISS)
Regulation of response to DNA damage checkpoint signaling GO:1902153
Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling.
1 Q9NQ88 (/IMP)
Positive regulation of hexokinase activity GO:1903301
Any process that activates or increases the frequency, rate or extent of hexokinase activity.
1 Q9NQ88 (/IDA)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
5 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS) Q8BZA9 (/ISS) Q8BZA9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q8BZA9 (/IDA) Q8BZA9 (/IDA) Q9NQ88 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 B1WAX6 (/ISS) Q1JQA7 (/ISS) Q4V7R0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8BZA9 (/IDA) Q8BZA9 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A0A0U1RQD1 (/IDA) Q9NQ88 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8BZA9 (/ISO) Q8BZA9 (/ISO)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q9NQ88 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9NQ88 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q9NQ88 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9NQ88 (/TAS)
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