The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Acetolactate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thiamine pyrophosphate binding GO:0030976
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
59 P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA)
(49 more)
Acetolactate synthase activity GO:0003984
Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
34 P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA)
(24 more)
Tartronate-semialdehyde synthase activity GO:0009028
Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2).
33 P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA)
(23 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
33 P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA)
(23 more)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
33 P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA) P0AEP7 (/IDA)
(23 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
26 P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA)
(16 more)
Acetolactate synthase activity GO:0003984
Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
17 P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP) P00893 (/IMP)
(7 more)
Acetolactate synthase activity GO:0003984
Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
14 Q8EC82 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KVV7 (/ISS) Q9KVV7 (/ISS)
(4 more)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
6 P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA)
Acetolactate synthase activity GO:0003984
Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
1 P36620 (/IGI)
Acetolactate synthase activity GO:0003984
Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
1 C8V916 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P17597 (/IPI)
Tartronate-semialdehyde synthase activity GO:0009028
Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2).
1 Q4KG06 (/ISS)
Benzoin aldolase activity GO:0047695
Catalysis of the reaction: benzoin = 2 benzaldehyde.
1 Q5LQV0 (/ISS)
Sulfoacetaldehyde acetyltransferase activity GO:0050487
Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde.
1 Q5LKS2 (/ISS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glyoxylate catabolic process GO:0009436
The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.
33 P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP)
(23 more)
Glycolate catabolic process GO:0046296
The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid).
33 P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP) P0AEP7 (/IMP)
(23 more)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
28 P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA)
(18 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
26 P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA)
(16 more)
Branched-chain amino acid biosynthetic process GO:0009082
The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
15 P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P9WG41 (/IDA) P9WG41 (/IDA) P9WG41 (/IDA) P9WG41 (/IDA)
(5 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
14 Q8EC82 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KVV7 (/ISS) Q9KVV7 (/ISS)
(4 more)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
14 Q8EC82 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KP90 (/ISS) Q9KVV7 (/ISS) Q9KVV7 (/ISS)
(4 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
10 A0A1D8PJF9 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
10 A0A1D8PJF9 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP) P9WG41 (/IMP)
Branched-chain amino acid biosynthetic process GO:0009082
The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
7 C8V916 (/IMP) P07342 (/IMP) P07342 (/IMP) P07342 (/IMP) P07342 (/IMP) P07342 (/IMP) P07342 (/IMP)
Branched-chain amino acid metabolic process GO:0009081
The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
1 C8V916 (/RCA)
Branched-chain amino acid biosynthetic process GO:0009082
The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
1 C8V916 (/ISA)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
1 P36620 (/EXP)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
1 P36620 (/IGI)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
1 P36620 (/IC)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
1 P36620 (/EXP)
Glyoxylate catabolic process GO:0009436
The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.
1 Q4KG06 (/ISS)
Taurine catabolic process GO:0019529
The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.
1 Q5LKS2 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA) P00893 (/IDA)
(7 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA) P9WG41 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P07342 (/HDA) P07342 (/HDA) P07342 (/HDA) P07342 (/HDA) P07342 (/HDA) P07342 (/HDA) P36620 (/HDA)
Acetolactate synthase complex GO:0005948
A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.
6 P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA) P07342 (/IDA)
Acetolactate synthase complex GO:0005948
A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.
1 C8V916 (/ISA)
Acetolactate synthase complex GO:0005948
A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.
1 P36620 (/ISS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 P17597 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 P17597 (/IDA)
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