The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADH-ubiquinone oxidoreductase 51kDa subunit
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: NADH dehydrogenase [ubiquinone] flavoprotein 1, mi...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
FMN binding GO:0010181
Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
62 P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS)
(52 more)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
62 P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP)
(52 more)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
62 P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS) P31979 (/ISS)
(52 more)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
62 P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP)
(52 more)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
11 Q608Y1 (/ISS) Q746S7 (/ISS) Q746S7 (/ISS) Q83BR0 (/ISS) Q87ZQ5 (/ISS) Q87ZQ5 (/ISS) Q87ZQ5 (/ISS) Q87ZQ5 (/ISS) Q87ZQ5 (/ISS) Q87ZQ5 (/ISS)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P49821 (/IPI) P49821 (/IPI) Q91YT0 (/IPI)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
2 P49821 (/NAS) P49821 (/NAS)
Ferredoxin hydrogenase activity GO:0008901
Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2.
2 Q3ZA53 (/ISS) Q3ZA53 (/ISS)
Formate dehydrogenase (NAD+) activity GO:0008863
Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.
1 Q608U7 (/ISS)
NADH dehydrogenase (quinone) activity GO:0050136
Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
1 Q5LPS2 (/ISS)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
64 P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP)
(54 more)
Aerobic electron transport chain GO:0019646
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
7 A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
5 Q608Y1 (/ISS) Q746S7 (/ISS) Q746S7 (/ISS) Q83BR0 (/ISS) Q8EI33 (/ISS)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
2 Q5B1F1 (/RCA) Q5B1F1 (/RCA)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
2 P49821 (/IC) P49821 (/IC)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
2 P49821 (/NAS) P49821 (/NAS)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
2 P49821 (/TAS) P49821 (/TAS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 Q59TD5 (/IMP) Q59TD5 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q59TD5 (/IMP) Q59TD5 (/IMP)
Mitochondrial respiratory chain complex I assembly GO:0032981
The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
2 P49821 (/TAS) P49821 (/TAS)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 Q59TD5 (/IMP) Q59TD5 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
2 Q59TD5 (/IMP) Q59TD5 (/IMP)
Mitochondrial ATP synthesis coupled electron transport GO:0042775
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
2 P49821 (/IMP) P49821 (/IMP)
Single-species biofilm formation on inanimate substrate GO:0044011
A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
2 Q59TD5 (/IMP) Q59TD5 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q17880 (/IMP)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
1 Q17880 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q17880 (/IMP)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
1 Q17880 (/IMP)
Defecation GO:0030421
The expulsion of feces from the rectum.
1 Q17880 (/IMP)
Mitochondrial respiratory chain complex assembly GO:0033108
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.
1 Q17880 (/IMP)
Inductive cell migration GO:0040039
Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans.
1 Q17880 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q17880 (/IMP)
Mitochondrial ATP synthesis coupled electron transport GO:0042775
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
1 Q91YT0 (/ISO)
Pharyngeal pumping GO:0043050
The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes.
1 Q17880 (/IMP)
Dauer exit GO:0043054
Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development.
1 Q17880 (/IMP)
Cellular respiration GO:0045333
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
1 Q17880 (/IMP)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 Q17880 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q608U7 (/ISS)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
64 P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA)
(54 more)
NADH dehydrogenase complex GO:0030964
An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.
63 P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA)
(53 more)
Plasma membrane respiratory chain complex I GO:0045272
A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.
62 P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA) P31979 (/IDA)
(52 more)
Plasma membrane respiratory chain complex I GO:0045272
A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.
62 P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP) P31979 (/IMP)
(52 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 B4DE93 (/IDA) E5KNH5 (/IDA) E5KNH5 (/IDA) G3V0I5 (/IDA) P49821 (/IDA) P49821 (/IDA) Q17880 (/IDA) Q57VW8 (/IDA) Q9FNN5 (/IDA) Q9FNN5 (/IDA)
Mitochondrial respiratory chain complex I, peripheral segment GO:0042652
The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.
7 A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP) A2QJ32 (/IMP)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 B4DE93 (/IDA) E5KNH5 (/IDA) E5KNH5 (/IDA) G3V0I5 (/IDA) P49821 (/IDA) P49821 (/IDA)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
5 P25708 (/IDA) P49821 (/IDA) P49821 (/IDA) Q9FNN5 (/IDA) Q9FNN5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O94500 (/HDA) Q91YT0 (/HDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P49821 (/NAS) P49821 (/NAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P49821 (/TAS) P49821 (/TAS)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
2 P49821 (/IMP) P49821 (/IMP)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
2 Q17880 (/ISS) Q54I90 (/ISS)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
2 P49821 (/NAS) P49821 (/NAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q59TD5 (/IDA) Q59TD5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q91YT0 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q54I90 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q57VW8 (/RCA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q91YT0 (/HDA)
Mitochondrial respiratory chain complex I GO:0005747
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
1 Q91YT0 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q91YT0 (/ISO)
Formate dehydrogenase complex GO:0009326
An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2).
1 Q608U7 (/ISS)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 Q54I90 (/ISS)
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