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CATH Superfamily 3.40.50.1100

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: L-threonine dehydratase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
 20 A0FKE6 (/IDA) O94634 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA)
(10 more)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
 14 P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA)
(4 more)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
 14 P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA)
(4 more)
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
 7 P00927 (/IMP) P00927 (/IMP) P00927 (/IMP) P00927 (/IMP) P00927 (/IMP) Q9ZSS6 (/IMP) Q9ZSS6 (/IMP)
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
 7 Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
 2 A0FKE6 (/ISS) P25306 (/ISS)
L-serine ammonia-lyase activity GO:0003941
Catalysis of the reaction: L-serine = pyruvate + NH3.
 1 P25306 (/IDA)
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
 1 C8V6Q6 (/RCA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 1 P25306 (/IPI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Threonine metabolic process GO:0006566
The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
 113 P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS) P20506 (/ISS)
(103 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
 22 P00927 (/IMP) P00927 (/IMP) P00927 (/IMP) P00927 (/IMP) P00927 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP)
(12 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
 17 A0FKE6 (/IDA) O94634 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA)
(7 more)
Threonine metabolic process GO:0006566
The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
 14 P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA) P04968 (/IDA)
(4 more)
Branched-chain amino acid biosynthetic process GO:0009082
The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
 14 P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP) P04968 (/IMP)
(4 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
 7 Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS) Q9KVW1 (/ISS)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
 5 P00927 (/IGI) P00927 (/IGI) P00927 (/IGI) P00927 (/IGI) P00927 (/IGI)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
 2 A0FKE6 (/IDA) P25306 (/IDA)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
 2 Q9ZSS6 (/TAS) Q9ZSS6 (/TAS)
Defense response to insect GO:0002213
A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.
 1 P25306 (/IDA)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
 1 C8V6Q6 (/RCA)
L-serine catabolic process GO:0006565
The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
 1 P25306 (/IDA)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
 1 Q59P56 (/IMP)
Response to insect GO:0009625
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.
 1 P25306 (/IDA)
Response to insect GO:0009625
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.
 1 P25306 (/IEP)
Positive regulation of defense response GO:0031349
Any process that activates or increases the frequency, rate or extent of a defense response.
 1 P25306 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
 1 P25306 (/IDA)
Response to herbivore GO:0080027
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore.
 1 P25306 (/IDA)
Response to herbivore GO:0080027
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore.
 1 P25306 (/IEP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 9 P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA) P9WG95 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
 5 P00927 (/HDA) P00927 (/HDA) P00927 (/HDA) P00927 (/HDA) P00927 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 1 O94634 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
 1 O94634 (/ISS)