The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Cysteine synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cysteine synthase activity GO:0004124
Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
40 B9DFR6 (/IDA) F4K5T2 (/IDA) G5EFH8 (/IDA) O01592 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O22682 (/IDA)
(30 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 B9DFR6 (/IPI) P47998 (/IPI) P47998 (/IPI) P9WP55 (/IPI) P9WP55 (/IPI) P9WP55 (/IPI) P9WP55 (/IPI) P9WP55 (/IPI) P9WP55 (/IPI) P9WP55 (/IPI)
(8 more)
Cysteine synthase activity GO:0004124
Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
17 A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS)
(7 more)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
14 F4K5T2 (/IDA) G5EFH8 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA) P9WP55 (/IDA)
(4 more)
Cystathionine beta-synthase activity GO:0004122
Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
11 G5EFH8 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
(1 more)
L-3-cyanoalanine synthase activity GO:0050017
Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine.
7 O45679 (/IDA) Q1KLZ1 (/IDA) Q1KLZ2 (/IDA) Q43153 (/IDA) Q76MX2 (/IDA) Q9S757 (/IDA) Q9S757 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
5 P37887 (/IPI) P37887 (/IPI) P37887 (/IPI) P37887 (/IPI) P37887 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
Cysteine synthase activity GO:0004124
Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
4 Q9S6Z7 (/IMP) Q9S757 (/IMP) Q9S757 (/IMP) Q9SXS7 (/IMP)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
2 Q9S757 (/IDA) Q9S757 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q43725 (/IPI) Q43725 (/IPI)
L-3-cyanoalanine synthase activity GO:0050017
Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine.
2 Q9S757 (/IMP) Q9S757 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 B9DFR6 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 B9DFR6 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q93244 (/IPI)
L-cysteine desulfhydrase activity GO:0080146
Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+.
1 F4K5T2 (/IDA)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cysteine biosynthetic process from serine GO:0006535
The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.
25 O01592 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O05393 (/IDA) O45679 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
(15 more)
Cysteine biosynthetic process from serine GO:0006535
The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.
17 A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS) A0A1J9VES8 (/ISS)
(7 more)
Cysteine biosynthetic process from serine GO:0006535
The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.
14 P47998 (/TAS) P47998 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS)
(4 more)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
10 O05393 (/IMP) O05393 (/IMP) O05393 (/IMP) O05393 (/IMP) O05393 (/IMP) P37887 (/IMP) P37887 (/IMP) P37887 (/IMP) P37887 (/IMP) P37887 (/IMP)
Cysteine biosynthetic process GO:0019344
The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
7 B9DFR6 (/IDA) P47999 (/IDA) P47999 (/IDA) P47999 (/IDA) Q9S6Z7 (/IDA) Q9S757 (/IDA) Q9S757 (/IDA)
Double fertilization forming a zygote and endosperm GO:0009567
Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana.
6 B9DFR6 (/IGI) P47998 (/IGI) P47998 (/IGI) P47999 (/IGI) P47999 (/IGI) P47999 (/IGI)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
6 B9DFR6 (/IGI) P47998 (/IGI) P47998 (/IGI) P47999 (/IGI) P47999 (/IGI) P47999 (/IGI)
Methionine catabolic process GO:0009087
The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
5 P37887 (/IMP) P37887 (/IMP) P37887 (/IMP) P37887 (/IMP) P37887 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
5 P47998 (/IEP) P47998 (/IEP) P47999 (/IEP) P47999 (/IEP) P47999 (/IEP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
5 P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
5 P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
5 P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
3 P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Cysteine metabolic process GO:0006534
The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
2 Q43153 (/IDA) Q76MX2 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 Q9S757 (/IMP) Q9S757 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
2 P47998 (/IMP) P47998 (/IMP)
Photosynthetic acclimation GO:0009643
A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light.
2 O22682 (/IMP) O22682 (/IMP)
Fruit ripening, climacteric GO:0009836
A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset.
2 Q1KLZ1 (/IDA) Q1KLZ2 (/IDA)
Regulation of hydrogen peroxide metabolic process GO:0010310
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.
2 O22682 (/IMP) O22682 (/IMP)
Photosynthesis GO:0015979
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
2 O22682 (/IMP) O22682 (/IMP)
Cysteine biosynthetic process GO:0019344
The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
2 P47998 (/IMP) P47998 (/IMP)
Cyanide metabolic process GO:0019499
The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain.
2 Q43153 (/IDA) Q76MX2 (/IDA)
Cyanide metabolic process GO:0019499
The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain.
2 Q9S757 (/TAS) Q9S757 (/TAS)
Cyanide catabolic process GO:0019500
The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration.
2 Q9S757 (/IMP) Q9S757 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 P47998 (/IDA) P47998 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 P47998 (/IMP) P47998 (/IMP)
Detoxification of nitrogen compound GO:0051410
Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
2 Q9S757 (/TAS) Q9S757 (/TAS)
Root hair cell development GO:0080147
The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state.
2 Q9S757 (/IMP) Q9S757 (/IMP)
Regulation of superoxide metabolic process GO:0090322
Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
2 O22682 (/IMP) O22682 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q93244 (/IGI)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q93244 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 F4K5T2 (/IMP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 Q1KLZ2 (/IDA)
Sulfur compound biosynthetic process GO:0044272
The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
1 G5EFH8 (/IDA)
Pollen tube development GO:0048868
The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure.
1 B9DFR6 (/IMP)
Cysteine homeostasis GO:0080145
Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell.
1 F4K5T2 (/IDA)
Cysteine homeostasis GO:0080145
Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell.
1 F4K5T2 (/IMP)
Stress response to cadmium ion GO:1990170
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus.
1 F4K5T2 (/IMP)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
12 P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA) P9WP55 (/HDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS) P9WP55 (/TAS)
(2 more)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
10 B9DFR6 (/IDA) O22682 (/IDA) O22682 (/IDA) P47998 (/IDA) P47998 (/IDA) P47999 (/IDA) P47999 (/IDA) P47999 (/IDA) Q9S757 (/IDA) Q9S757 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 B9DFR6 (/IDA) P47999 (/IDA) P47999 (/IDA) P47999 (/IDA) Q9S757 (/IDA) Q9S757 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
6 B9DFR6 (/IDA) P47998 (/IDA) P47998 (/IDA) P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
5 P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA) P37887 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
5 P47998 (/IDA) P47998 (/IDA) P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
3 P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
3 P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
3 P47999 (/TAS) P47999 (/TAS) P47999 (/TAS)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
3 P47999 (/IDA) P47999 (/IDA) P47999 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P47998 (/IDA) P47998 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
2 P47998 (/IDA) P47998 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 P47998 (/IDA) P47998 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P47998 (/IDA) P47998 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P47998 (/ISS) P47998 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P47998 (/IDA) P47998 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P47998 (/IDA) P47998 (/IDA)
Thylakoid lumen GO:0031977
The volume enclosed by a thylakoid membrane.
2 O22682 (/IDA) O22682 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q93244 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 G5EFH8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 B9DFR6 (/TAS)
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
1 Q93244 (/HDA)
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