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CATH Superfamily 3.40.50.1100

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Cysteine synthase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase. [EC: 2.5.1.113]
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)-S-L-cysteine + phosphate.
  • The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor.
  • The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O(3)-acetyl-L-serine (cf. EC 2.5.1.65).
  • Formerly EC 2.5.1.n5.
 132 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51 A0A045IS51
(122 more...)
O-ureido-L-serine synthase. [EC: 2.6.99.3]
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate.
  • The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
  • Also catalyzes EC 2.5.1.47.
 1 D2Z027
Cysteine synthase. [EC: 2.5.1.47]
O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
  • Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.
  • Not identical with EC 2.5.1.51, EC 2.5.1.52 and EC 2.5.1.53.
  • Formerly EC 4.2.99.8.
 1 D2Z027
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